Human NFKBID Recombinant Protein (RPPB4090)

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SKU:
RPPB4090
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NFKBID
Synonyms:
NF-kappa-B inhibitor delta
Synonyms:
I-kappa-B-delta
Synonyms:
IkB-delta
Synonyms:
IkappaBdelta
Source:
Escherichia Coli
Uniprot:
Q8NI38
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Description

Product Name:Human NFKBID Recombinant Protein
Product Code:RPPB4090
Size:20µg
Species:Human
Target:NFKBID
Synonyms:NF-kappa-B inhibitor delta, I-kappa-B-delta, IkB-delta, IkappaBdelta, IkappaBNS, T-cell activation NFKB-like protein, TA-NFKBH, NFKBID, IKBNS.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NFKBID solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEAGPWR VSAPPSGPPQ FPAVVPGPSL EVARAHMLAL GPQQLLAQDE EGDTLLHLFA ARGLRWAAYA AAEVLQVYRR LDIREHKGKT PLLVAAAANQ PLIVEDLLNL GAEPNAADHQ GRSVLHVAAT YGLPGVLLAV LNSGVQVDLE ARDFEGLTPL HTAILALNVA MRPSDLCPRV LSTQARDRLD CVHMLLQMGA NHTSQEIKSN KTVLHLAVQA ANPTLVQLLL ELPRGDLRTF VNMKAHGNTA LHMAAALPPG PAQEAIVRHL LAAGADPTLR NLENEQPVHL LRPGPGPEGL RQLLKRSRVA PPGLSS

NFKBID belongs to the IkB family of proteins which contains four groups (IkB-alpha, IkB-beta, IkB-gamma, IkB-epsilon). NFKBID takes part in regulating inflammatory responses and cytokine, IL-2 and IL-6 expression through NFkB activity. NFKBID has 3 known alternative spliced isoforms, and is associated with RelB, NFkB p50 and NFkB p65 in nucleus. NFKBID is involeved in thymocyte selection in response to TCR induction.

NFKBID Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 336 amino acids (1-313) and having a molecular mass of 35.9 kDa.NFKBID is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: nucleus

Molecular Function:NF-kappaB binding

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of T cell differentiation in the thymus; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response

UniProt Code:Q8NI38
NCBI GenInfo Identifier:74751323
NCBI Gene ID:84807
NCBI Accession:Q8NI38.1
UniProt Secondary Accession:Q8NI38,Q8NI39, Q9BRG9,
UniProt Related Accession:Q8NI38
Molecular Weight:150
NCBI Full Name:NF-kappa-B inhibitor delta
NCBI Synonym Full Names:nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NCBI Official Symbol:NFKBID  
NCBI Official Synonym Symbols:TA-NFKBH; IkappaBNS  
NCBI Protein Information:NF-kappa-B inhibitor delta; ikB-delta; ikappaBdelta; I-kappa-B-delta; T-cell activation NFKB-like protein
UniProt Protein Name:NF-kappa-B inhibitor delta
UniProt Synonym Protein Names:I-kappa-B-delta; IkB-delta; IkappaBdelta; IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH
Protein Family:NF-kappa-B inhibitor
UniProt Gene Name:NFKBID  
UniProt Entry Name:IKBD_HUMAN
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