Human NEURL2 Recombinant Protein (RPPB4085)

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SKU:
RPPB4085
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
NEURL2
Synonyms:
neuralizedhomolog 2
Synonyms:
C20orf163
Synonyms:
OZZ
Synonyms:
Ozz-E3
Source:
Escherichia Coli
Uniprot:
Q9BR09
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Description

Product Name:Human NEURL2 Recombinant Protein
Product Code:RPPB4085
Size:10µg
Species:Human
Target:NEURL2
Synonyms: neuralizedhomolog 2, C20orf163, OZZ, Ozz-E3, Neuralized-like protein 2, NeuralizedHomolog 2, NEURL2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NEURL2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAASEP VDSGALWGLE RPEPPPTRFH RVHGANIRVD PSGTRATRVE SFAHGVCFSR EPLAPGQVFL VEIEEKELGW CGHLRLGLTA LDPASLAPVP EFSLPDLVNL GHTWVFAITR HHNRVPREGR PEAEAAAPSR PPTLLVEPYL RIEQFRIPRDRLVGRSRPGL YSHLLDQLYE LNVLPPTARR SRLGVLFCPR PDGTADMHII INGEDMGPSA RGLPAAQPLY AVVDVFASTK SVRLVQLEYG LPSLQTLCRL VIQRSMVHRL AIDGLHLPKE LKDFCKYE

Neuralized Homolog 2 (NEURL2) takes part in the process of myofiber differentiation and maturation. NEURL2 is probable substrate-recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. NEURL2 regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.

NEURL2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285) and having a molecular mass of 34.1 kDa.NEURL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NEURL2: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: muscle tendon junction; VCB complex

Biological Process: protein ubiquitination; sarcomere organization

NCBI Summary:This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q9BR09
NCBI GenInfo Identifier:33301415
NCBI Gene ID:
NCBI Accession:Q9BR09.1
UniProt Secondary Accession:Q9BR09,Q3KR34,
Molecular Weight:31,690 Da
NCBI Full Name:Neuralized-like protein 2
UniProt Protein Name:Neuralized-like protein 2
Protein Family:Neuralized-like protein
UniProt Gene Name:NEURL2  
UniProt Entry Name:NEUL2_HUMAN
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