Human NANP Recombinant Protein (RPPB1996)

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SKU:
RPPB1996
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
NANP
Synonyms:
N-acylneuraminate-9-phosphatase
Synonyms:
Haloacid dehalogenase-like hydrolase domain-containing protein 4
Synonyms:
Neu5Ac-9-Pase
Synonyms:
NANP
Source:
Escherichia Coli
Uniprot:
Q8TBE9
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Description

Product Name:Human NANP Recombinant Protein
Product Code:RPPB1996
Size:20µg
Species:Human
Target:NANP
Synonyms:N-acylneuraminate-9-phosphatase, Haloacid dehalogenase-like hydrolase domain-containing protein 4, Neu5Ac-9-Pase, NANP, HDHD4, MGC26833, C20orf147, dJ694B14.3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The NANP solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGLS RVRAVFFDLD NTLIDTAGAS RRGMLEVIKL LQSKYHYKEE AEIICDKVQV KLSKECFHPY NTCITDLRTS HWEEAIQETK GGAANRKLAE ECYFLWKSTR LQHMTLAEDV KAMLTELRKE VRLLLLTNGD RQTQREKIEA CACQSYFDAV VVGGEQREEK PAPSIFYYCC NLLGVQPGDC VMVGDTLETD IQGGLNAGLK ATVWINKNGI VPLKSSPVPH YMVSSVLELP ALLQSIDCKV SMST

N-acylneuraminate-9-phosphatase (NANP) belongs to the haloacid dehalogenase (HAD) family and is responsible for dephosphorylating N-acylneuraminate 9-phosphate to form N-acylneuraminate (N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate). The catalytic activity of NANP is relies on the presence of magnesium and is inhibited by vanadate and calcium, which is typical of the HAD phosphatase family.

NANP Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 284 amino acids (1-248 a.a.) and having a molecular mass of 31.9kDa. The NANP is purified by proprietary chromatographic techniques.

UniProt Protein Function:HDHD4: Belongs to the HAD-like hydrolase superfamily. NANP family.
UniProt Protein Details:

Protein type:EC 3.1.3.29; Phosphatase (non-protein); Carbohydrate Metabolism - amino sugar and nucleotide sugar

Chromosomal Location of Human Ortholog: 20p11.1

Cellular Component: cytosol

Molecular Function:N-acylneuraminate-9-phosphatase activity

Biological Process: N-acetylglucosamine biosynthetic process; N-acetylneuraminate biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; dephosphorylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

UniProt Code:Q8TBE9
NCBI GenInfo Identifier:23308749
NCBI Gene ID:140838
NCBI Accession:NP_689880.1
UniProt Secondary Accession:Q8TBE9,Q5JYN8, Q8TE97, Q9Y3N0, B3KP12,
UniProt Related Accession:Q8TBE9
Molecular Weight:27,813 Da
NCBI Full Name:N-acylneuraminate-9-phosphatase
NCBI Synonym Full Names:N-acetylneuraminic acid phosphatase
NCBI Official Symbol:NANP  
NCBI Official Synonym Symbols:HDHD4; C20orf147; dJ694B14.3  
NCBI Protein Information:N-acylneuraminate-9-phosphatase
UniProt Protein Name:N-acylneuraminate-9-phosphatase
UniProt Synonym Protein Names:Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-Pase
Protein Family:N-acylneuraminate-9-phosphatase
UniProt Gene Name:NANP  
UniProt Entry Name:NANP_HUMAN
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