Human MYL6B Recombinant Protein (RPPB4038)

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SKU:
RPPB4038
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MYL6B
Synonyms:
Myosin light chain 6B
Synonyms:
Myosin light chain 1 slow-twitch muscle A isoform
Synonyms:
MLC1sa
Synonyms:
Smooth muscle and nonmuscle myosin light chain alkali 6B
Source:
Escherichia Coli
Uniprot:
P14649
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Description

Product Name:Human MYL6B Recombinant Protein
Product Code:RPPB4038
Size:20µg
Species:Human
Target:MYL6B
Synonyms:Myosin light chain 6B, Myosin light chain 1 slow-twitch muscle A isoform, MLC1sa, Smooth muscle and nonmuscle myosin light chain alkali 6B, MYL6B, MLC1SA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MYL6B solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPPKKDV PVKKPAGPSI SKPAAKPAAA GAPPAKTKAE PAVPQAPQKT QEPPVDLSKV VIEFNKDQLE EFKEAFELFD RVGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEL KSRRVDFETF LPMLQAVAKN RGQGTYEDYL EGFRVFDKEG NGKVMGAELR HVLTTLGEKM TEEEVETVLA GHEDSNGCIN YEAFLKHILS V

Myosin Light Chain 6B (MYL6B) is a heavy chain regulator located in smooth muscle and non-muscle Myosin complexes. Contractile activity in the smooth muscle is regulated by the calcium/calmodulin-dependent phosphorylation of Myosin light chain by Myosin light chain kinase. MYL6B doesn’t bind calcium during contraction. MYL6B is mostly found as a hexamer consisting of 4 light chains and 2 heavy chains. MYL6B usually interacts with Myosin Va, an Actin based motor which moves in large steps. MYL6B is expressed in the majority of tissues with neurons, while smooth muscle tissue having the highest expression.

MYL6B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (1-208) and having a molecular mass of 25.2 kDa.The MYL6B is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:MYL6B: Regulatory light chain of myosin. Does not bind calcium.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Contractile

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytosol; muscle myosin complex; myosin complex; unconventional myosin complex

Molecular Function:motor activity; protein binding; structural constituent of muscle

Biological Process: muscle contraction; muscle filament sliding; skeletal muscle development

NCBI Summary:Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
UniProt Code:P14649
NCBI GenInfo Identifier:127153
NCBI Gene ID:140465
NCBI Accession:P14649.1
UniProt Related Accession:P14649
Molecular Weight:22,764 Da
NCBI Full Name:Myosin light chain 6B
NCBI Synonym Full Names:myosin light chain 6B
NCBI Official Symbol:MYL6B  
NCBI Official Synonym Symbols:MLC1SA  
NCBI Protein Information:myosin light chain 6B
UniProt Protein Name:Myosin light chain 6B
UniProt Synonym Protein Names:Myosin light chain 1 slow-twitch muscle A isoform; MLC1sa; Smooth muscle and nonmuscle myosin light chain alkali 6B
Protein Family:Myosin
UniProt Gene Name:MYL6B  
UniProt Entry Name:MYL6B_HUMAN
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