Human MYL4 Recombinant Protein (RPPB4034)

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SKU:
RPPB4034
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MYL4
Synonyms:
Myosin light chain 4 alkali atrial embryonic
Synonyms:
ALC1
Synonyms:
AMLC
Synonyms:
GT1
Source:
Escherichia Coli
Uniprot:
P12829
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Description

Product Name:Human MYL4 Recombinant Protein
Product Code:RPPB4034
Size:20µg
Species:Human
Target:MYL4
Synonyms:Myosin light chain 4 alkali atrial embryonic, ALC1, AMLC, GT1, Myosin light chain 1 embryonic muscle/atrial isoform, Myosin light chain alkali GT-1 isoform, PRO1957, MLC1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MYL4 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 150mM NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA DQIEEFKEAF SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK PKPEEMNVKM LDFETFLPIL QHISRNKEQG TYEDFVEGLR VFDKESNGTV MGAELRHVLA TLGEKMTEAE VEQLLAGQED ANGCINYEAF VKHIMSGLEH HHHHH

MYL4 is a hexameric ATPase cellular motor protein which is composed of two nonphosphorylatable alkali light chains, two heavy chains and two phosphorylatable regulatory light chains. MYL4 encodes a myosin alkali light chain which is located in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein were found for this gene.

MYL4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-197 a.a.) and having a molecular mass of 22.6kDa.MYL4 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MYL4: Regulatory light chain of myosin. Does not bind calcium.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding; Contractile

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: A band; cytosol

Molecular Function:actin filament binding; actin monomer binding

Biological Process: cardiac muscle contraction; muscle filament sliding; positive regulation of ATPase activity; regulation of the force of heart contraction

NCBI Summary:Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P12829
NCBI GenInfo Identifier:127138
NCBI Gene ID:4635
NCBI Accession:P12829.3
UniProt Secondary Accession:P12829,P11783, D3DXJ7,
UniProt Related Accession:P12829
Molecular Weight:21,565 Da
NCBI Full Name:Myosin light chain 4
NCBI Synonym Full Names:myosin light chain 4
NCBI Official Symbol:MYL4  
NCBI Official Synonym Symbols:GT1; ALC1; AMLC; PRO1957  
NCBI Protein Information:myosin light chain 4
UniProt Protein Name:Myosin light chain 4
UniProt Synonym Protein Names:Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain alkali GT-1 isoform
Protein Family:Myosin
UniProt Gene Name:MYL4  
UniProt Entry Name:MYL4_HUMAN
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