Human MRPS2 Recombinant Protein (RPPB4006)

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SKU:
RPPB4006
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MRPS2
Synonyms:
Mitochondrial ribosomal protein S2
Synonyms:
CGI-91
Synonyms:
MRP-S2
Synonyms:
S2mt
Source:
Escherichia Coli
Uniprot:
Q9Y399
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Description

Product Name:Human MRPS2 Recombinant Protein
Product Code:RPPB4006
Size:20µg
Species:Human
Target:MRPS2
Synonyms:Mitochondrial ribosomal protein S2, CGI-91, MRP-S2, S2mt, 28S ribosomal protein S2, mitochondrial, MRPS2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MRPS2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMATSSAA LPRILGAGAR APSRWLGFLG KATPRPARPS RRTLGSATAL MIRESEDSTD FNDKILNEPL KHSDFFNVKE LFSVRSLFDA RVHLGHKAGC RHRFMEPYIF GSRLDHDIID LEQTATHLQL ALNFTAHMAY RKGIILFISR NRQFSYLIEN MARDCGEYAH TRYFRGGMLT NARLLFGPTV RLPDLIIFLH TLNNIFEPHV AVRDAAKMNI PTVGIVDTNC NPCLITYPVP GNDDSPLAVH LYCRLFQTAI TRAKEKRQQV EALYRLQGQK EPGDQGPAHP PGADMSHSL

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit and have about 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Mitochondrial Ribosomal Protein S2 (MRPS2) is a 28S subunit protein which is a part of the ribosomal protein S2 family and comprises a 12S rRNA and about 30 distinct proteins.

MRPS2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 319 amino acids (1-296) and having a molecular mass of 35.6 kDa.MRPS2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MRPS2: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Protein Details:

Protein type:Mitochondrial; Ribosomal; Translation

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: mitochondrial small ribosomal subunit; mitochondrion

Molecular Function:structural constituent of ribosome

Biological Process: mitochondrial translation; positive regulation of defense response to virus by host; translation

NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Code:Q9Y399
NCBI GenInfo Identifier:24212389
NCBI Gene ID:51116
NCBI Accession:Q9Y399.1
UniProt Secondary Accession:Q9Y399,Q5T899, Q9BSQ4,
UniProt Related Accession:Q9Y399
Molecular Weight:33,249 Da
NCBI Full Name:28S ribosomal protein S2, mitochondrial
NCBI Synonym Full Names:mitochondrial ribosomal protein S2
NCBI Official Symbol:MRPS2  
NCBI Official Synonym Symbols:S2mt; CGI-91; MRP-S2  
NCBI Protein Information:28S ribosomal protein S2, mitochondrial
UniProt Protein Name:28S ribosomal protein S2, mitochondrial
Protein Family:28S ribosomal protein
UniProt Gene Name:MRPS2  
UniProt Entry Name:RT02_HUMAN
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