Human MRPL48 Recombinant Protein (RPPB4005)
- SKU:
- RPPB4005
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- MRPL48
- Synonyms:
- Mitochondrial Ribosomal Protein L48
- MRP-L48
- L48MT
- 39SRibosomal Protein L48
- Source:
- Escherichia Coli
- Uniprot:
- Q96GC5
Description
| Product Name: | Human MRPL48 Recombinant Protein |
| Product Code: | RPPB4005 |
| Size: | 20µg |
| Species: | Human |
| Target: | MRPL48 |
| Synonyms: | Mitochondrial Ribosomal Protein L48, MRP-L48, L48MT, 39SRibosomal Protein L48, Mitochondrial, CGI-118, HSPC290, 39S ribosomal proteinL48, mitochondrial. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MRPL48 protein solution (1 mg/ml) containing 20mMTris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSGEKPIY SVGGILLSIS RPYKTKPTHG IGKYKHLIKA EEPKKKKGKVEVRAINLGTD YEYGVLNIHL TAYDMTLAES YAQYVHNLCN SLSIKVEESY AMPTKTIEVL QLQDQGSKMLLDSVLTTHER VVQISGLSAT FAEIFLEIIQ SSLPEGVRLSVKEHTEEDFK GRFKARPELE ELLAKLK |
Mitochondrial Ribosomal Protein L48, also known as MRPL48, is amammalian mitochondrial ribosomal protein which assists in protein synthesiswithin the mitochondrion. Mitochondrial ribosomes, mitoribosomes, consist of asmall 28S subunit and a large 39S subunit. They include an estimated 75%protein to rRNA composition while comparing to prokaryotic ribosomes, wherethis ratio is reversed.An additional dissimilarity between mammalian mitoribosomes & prokaryoticribosomes is that the latter contain a 5S rRNA. Between different species, theproteins containing the mitoribosome differ very much in sequence, as well as inbiochemical properties from time to time, which prevents easy recognition throughsequence homology. MRPL48 encodes a 39S subunit protein. A pseudogenecorresponding to MRPL48 is found on chromosome 6p.
MRPL48 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 207 amino acids (29-212 a.a) andhaving a molecular mass of 23.1kDa.MRPL48 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRPL48: Interacts with OXA1L. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: mitochondrial inner membrane; mitochondrial ribosome Molecular Function:protein binding |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q96GC5 |
| NCBI GenInfo Identifier: | 118573683 |
| NCBI Gene ID: | 51642 |
| NCBI Accession: | Q96GC5.2 |
| UniProt Secondary Accession: | Q96GC5,Q49AK7, Q4U2Q4, Q9P091, Q9Y5J0, B4DN34, |
| UniProt Related Accession: | Q96GC5 |
| Molecular Weight: | 21,749 Da |
| NCBI Full Name: | 39S ribosomal protein L48, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L48 |
| NCBI Official Symbol: | MRPL48 |
| NCBI Official Synonym Symbols: | L48MT; CGI-118; HSPC290; MRP-L48 |
| NCBI Protein Information: | 39S ribosomal protein L48, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L48, mitochondrial |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL48 |
| UniProt Entry Name: | RM48_HUMAN |
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