Human MRAS Recombinant Protein (RPPB3995)

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SKU:
RPPB3995
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MRAS
Synonyms:
Ras-related protein M-Ras
Synonyms:
Ras-related protein R-Ras3
Synonyms:
MRAS
Synonyms:
RRAS3
Source:
Escherichia Coli
Uniprot:
O14807
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Description

Product Name:Human MRAS Recombinant Protein
Product Code:RPPB3995
Size:20µg
Species:Human
Target:MRAS
Synonyms:Ras-related protein M-Ras, Ras-related protein R-Ras3, MRAS, RRAS3, M-RAs, R-RAS3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MRAS protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 40% glycerol, 200mM NaCl and 2mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT HKLQC

Ras-related protein M-Ras (MRAS) is a member of the RAS superfamily. These family members are membrane-anchored, intracellular signal transducers in charge of various normal cellular functions. They are oncogenically stimulated in a substantial fraction of tumors. MRAS serves as a significant signal transducer for novel upstream stimuli in controlling cell proliferation.

MRAS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (1-205 a.a.) and having a molecular mass of 25.7kDa. MRAS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MRas: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway. Belongs to the small GTPase superfamily. Ras family.
UniProt Protein Details:

Protein type:Oncoprotein; G protein, monomeric, Ras; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: plasma membrane

Molecular Function:GTPase activity; GTP binding; GTP-dependent protein binding

Biological Process: muscle development; metabolic process; multicellular organismal development; Ras protein signal transduction; actin cytoskeleton organization and biogenesis

NCBI Summary:This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:O14807
NCBI GenInfo Identifier:145386506
NCBI Gene ID:22808
NCBI Accession:NP_001078518.1
UniProt Related Accession:O14807
Molecular Weight:24 kDa
NCBI Full Name:ras-related protein M-Ras isoform 1
NCBI Synonym Full Names:muscle RAS oncogene homolog
NCBI Official Symbol:MRAS  
NCBI Official Synonym Symbols:NS11; M-RAs; RRAS3; R-RAS3  
NCBI Protein Information:ras-related protein M-Ras
UniProt Protein Name:Ras-related protein M-Ras
UniProt Synonym Protein Names:Ras-related protein R-Ras3
Protein Family:Ras-related protein
UniProt Gene Name:MRAS  
UniProt Entry Name:RASM_HUMAN
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