PE/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0685)

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SKU:
AGEL0685
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The CD47 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) - MIAP410 (AGEL0685) available at www.assaygenie.com is a specialized tool for researchers working with human, mouse, and rat samples. This antibody is designed for precise detection and analysis of CD47, a cell surface protein that plays a key role in immune regulation and evasion mechanisms in various biological processes.CD47, also known as integrin-associated protein, is recognized for its involvement in modulating immune responses and maintaining self-tolerance. As a target for cancer immunotherapy and immune checkpoint blockade, understanding the expression and function of CD47 is crucial in studies related to cancer, autoimmune diseases, and other immunological disorders.

The PE/Cyanine5.5 conjugation of this monoclonal antibody allows for fluorescence-based detection methods, making it ideal for flow cytometry and immunofluorescence assays. Its high specificity and reactivity with CD47 make it a valuable tool for researchers looking to investigate the role of this protein in diverse cell types and experimental settings.By using the CD47 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) - MIAP410 (AGEL0685), researchers can gain valuable insights into the functions and interactions of CD47, advancing our understanding of immune regulation and paving the way for innovative therapeutic strategies in the fields of immunology and cancer research.

Product Title:PE/Cyanine5.5 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0685
Size:25µg, 100µg
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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