Biotin Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0108)

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SKU:
AGEL0108
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Mouse
Isotype:
IgG1
Clone:
MIAP410
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The CD47 Monoclonal Antibody (MIAP410) is a cutting-edge research tool designed for studying CD47, a transmembrane protein involved in diverse cellular processes, including immune evasion and regulation of phagocytosis. This monoclonal antibody, conjugated with biotin for enhanced detection, is developed for use in human, mouse, and rat samples, offering versatility in experimental settings.CD47 plays a pivotal role in immune response modulation, particularly in the context of cancer development and progression. By interacting with receptors on immune cells, CD47 can influence the activity of macrophages and dendritic cells, impacting tumor immune evasion mechanisms. Research utilizing this antibody can contribute to a deeper understanding of CD47's functions in immune regulation and its implications for cancer therapy.

The biotin conjugation of this monoclonal antibody facilitates sensitive detection and precise localization of CD47 in various experimental setups, including immunohistochemistry and flow cytometry. Its high specificity and reactivity enable accurate quantification and analysis of CD47 expression levels, making it a valuable tool for investigations in immunology, oncology, and drug development. Unraveling the complex role of CD47 in immune modulation holds significant promise for advancing therapeutic strategies targeting cancer and other immune-related disorders.

Product Title:Biotin Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0108
Size:25µg, 100µg
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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