Human MOBKL1B Recombinant Protein (RPPB3985)

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SKU:
RPPB3985
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
MOBKL1B
Synonyms:
Mps one binder kinase activator-like 1B
Synonyms:
Mob1 alpha
Synonyms:
Mob1A
Synonyms:
Mob1 homolog 1B
Source:
Escherichia Coli
Uniprot:
Q9H8S9
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Description

Product Name:Human MOBKL1B Recombinant Protein
Product Code:RPPB3985
Size:20µg
Species:Human
Target:MOBKL1B
Synonyms:Mps one binder kinase activator-like 1B, Mob1 alpha, Mob1A, Mob1 homolog 1B, Protein Mob4B, MOBKL1B, C2orf6, MOB4B, MOBK1B, MOB1, MATS1, FLJ10788, FLJ11595.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MOBKL1B solution (0.5mg/ml) 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR

MOBKL1B is a member of the MOB1/phocein family. MOBKL1B stimulates the kinase activity of STK38 and STK38L. MOBKL1B also binds to and regulates downstream targets such as the NDR-family protein kinases and LATS1 kinase. Thus, MOBKL1B participates in cell cycle checkpoint control and tumor inhibition.

MOBKL1B Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 236 amino acids (1-216 a.a.) and having a molecular mass of 27.2kDa. The MOBKL1B is purified by proprietary chromatographic techniques.

UniProt Protein Function:MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytosol

Molecular Function:protein binding; metal ion binding

NCBI Summary:The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:Q9H8S9
NCBI GenInfo Identifier:56749356
NCBI Gene ID:55233
NCBI Accession:Q9H8S9.4
UniProt Related Accession:Q9H8S9
Molecular Weight:
NCBI Full Name:MOB kinase activator 1A
NCBI Synonym Full Names:MOB kinase activator 1A
NCBI Official Symbol:MOB1A  
NCBI Official Synonym Symbols:MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B  
NCBI Protein Information:MOB kinase activator 1A
UniProt Protein Name:MOB kinase activator 1A
UniProt Synonym Protein Names:Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B
Protein Family:MOB kinase activator
UniProt Gene Name:MOB1A  
UniProt Entry Name:MOB1A_HUMAN
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