Human MINA Recombinant Protein (RPPB3975)

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SKU:
RPPB3975
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MINA
Synonyms:
MYC Induced Nuclear Antigen
Synonyms:
MINA53
Synonyms:
MDIG
Synonyms:
60S RibosomalProtein L27a Histidine Hydroxylase
Source:
Escherichia Coli
Uniprot:
Q8IUF8
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Description

Product Name:Human MINA Recombinant Protein
Product Code:RPPB3975
Size:10µg
Species:Human
Target:MINA
Synonyms:MYC Induced Nuclear Antigen, MINA53, MDIG, 60S RibosomalProtein L27a Histidine Hydroxylase, Mineral Dust-Induced Gene Protein, HistoneLysine Demethylase MINA Ribosomal Oxygenase MINA, Nucleolar Protein 52, NO52, ROX,Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA, Myc-InducedNuclear Antigen, 53 KDa, Mineral Dust Induced Gene Protein, MYC-Induced NuclearAntigen, EC 1.14.11.-, Bifunctional lysine-specific demethylase andhistidyl-hydroxylase MINA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MINA protein solution (0.25mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSHMPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE QKPLLIQRDD PALATYYGSLFKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRIQEKLECYFGSLVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH PTVPLAREYSVEAEERIGRP VHEFMLKPGD LLYFPRGTIH QADTPAGLAH STHVTISTYQ NNSWGDFLLD TISGLVFDTAKEDVELRTGI PRQLLLQVES TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLPPYSAGDGAEL STPGGKLPRLDSVVRLQFKD HIVLTVLPDQ DQSDETQEKM VYIYHSLKNS RETHMMGNEE ETEFHGLRFP LSHLDALKQI WNSPAISVKDLKLTTDEEKE SLVLSLWTEC LIQVV

MYC Induced Nuclear Antigen, also known as MINA is an oxygenase whichcan function both as a histone lysine demethylase and a ribosomal histidine hydroxylase. MINA is involved in the demethylation of trimethylatedLys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNAexpression.  MINA also catalyzes thehydroxylation of 60S ribosomal protein L27a on His-39. In addition, MINA plays a significant role in cell growth andsurvival. MINA is implicated in ribosomebiogenesis, probably in the duration of the assembly process of pre-ribosomalparticles.

MINA Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 485 amino acids (1-465 a.a) andhaving a molecular mass of 54.9kDa.MINA is fused to a 20 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:MINA: Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Belongs to the MINA53/NO66 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function:dioxygenase activity; metal ion binding

Biological Process: transcription, DNA-dependent; ribosome biogenesis and assembly; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
UniProt Code:Q8IUF8
NCBI GenInfo Identifier:74750624
NCBI Gene ID:84864
NCBI Accession:Q8IUF8.1
UniProt Related Accession:Q8IUF8
Molecular Weight:
NCBI Full Name:Ribosomal oxygenase 2
NCBI Synonym Full Names:ribosomal oxygenase 2
NCBI Official Symbol:RIOX2  
NCBI Official Synonym Symbols:ROX; MDIG; MINA; NO52; JMJD10; MINA53  
NCBI Protein Information:ribosomal oxygenase 2
UniProt Protein Name:Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
UniProt Synonym Protein Names:60S ribosomal protein L27a histidine hydroxylase; Histone lysine demethylase MINA; MYC-induced nuclear antigen; Mineral dust-induced gene protein; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX
Protein Family:Bifunctional lysine-specific demethylase and histidyl-hydroxylase
UniProt Gene Name:MINA  
UniProt Entry Name:MINA_HUMAN
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