Human MECOM Recombinant Protein (RPPB3948)

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SKU:
RPPB3948
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MECOM
Synonyms:
MDS1 And EVI1 Complex Locus
Synonyms:
Ecotropic Virus Integration Site 1 Protein Homolog
Synonyms:
Myelodysplasia Syndrome-Associated Protein 1
Synonyms:
AML1-EVI-1
Source:
Escherichia Coli
Uniprot:
Q03112
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Description

Product Name:Human MECOM Recombinant Protein
Product Code:RPPB3948
Size:10µg
Species:Human
Target:MECOM
Synonyms:MDS1 And EVI1 Complex Locus, Ecotropic Virus Integration Site 1 Protein Homolog, Myelodysplasia Syndrome-Associated Protein 1, AML1-EVI-1, MDS1-EVI1, EVI1, MDS1, PRDM3, AML1-EVI-1 Fusion Protein, MDS1 And EVI1 Complex Locus Protein EVI1, MDS1 And EVI1 Complex Locus Protein MDS1, Oncogene EVI1, Zinc Finger Protein Evi1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MECOM protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMRSKGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS

MDS1 is a transcriptional regulator and oncoprotein which takes part in hematopoiesis, development, cell differentiation, apoptosis and proliferation. MDS1 is able to interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. Overexpression, as a result of translocation with the AML1 gene, is known to cause leukemia. A number of transcript variants encoding several different isoforms were found.

MECOM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-169 a.a) and having a molecular mass of 21.1kDa.MECOM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
NCBI Summary:The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Code:Q03112
NCBI GenInfo Identifier:145559472
NCBI Gene ID:2122
NCBI Accession:Q03112.2
UniProt Secondary Accession:Q03112,Q16122, Q5HYI1, Q6MZS6, Q8NEI5, A1L4F3, A8KA00 B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7,
UniProt Related Accession:Q13465,Q03112
Molecular Weight:117,232 Da
NCBI Full Name:MDS1 and EVI1 complex locus protein EVI1
NCBI Synonym Full Names:MDS1 and EVI1 complex locus
NCBI Official Symbol:MECOM  
NCBI Official Synonym Symbols:EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1  
NCBI Protein Information:MDS1 and EVI1 complex locus protein EVI1
UniProt Protein Name:MDS1 and EVI1 complex locus protein EVI1
UniProt Synonym Protein Names:Ecotropic virus integration site 1 protein homolog; EVI-1
Protein Family:MDS1 and EVI1 complex locus protein
UniProt Gene Name:MECOM  
UniProt Entry Name:EVI1_HUMAN
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