Human MAP2K3 Recombinant Protein (RPPB2565)

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SKU:
RPPB2565
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
MAP2K3
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 3
Synonyms:
MAP kinase kinase 3
Synonyms:
MAPKK 3
Synonyms:
MAPK/ERK kinase 3
Source:
Escherichia Coli
Uniprot:
P46734
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Description

Product Name:Human MAP2K3 Recombinant Protein
Product Code:RPPB2565
Size:5µg
Species:Human
Target:MAP2K3
Synonyms:Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, MAP2K3, MEK3, MKK3, PRKMK3.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:MAP2K3 solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS

Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) is a dual specificity protein kinase which is a member of the MAP kinase kinase family. MAP2K3 is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. MAP2K3 phosphorylates and consequently activates MAPK14/p38-MAPK. 

MAP2K3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 338 amino acids (1-318) and having a molecular mass of 38.3kDa. MAP2K3 is fused to 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
NCBI Summary:The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P46734
NCBI GenInfo Identifier:24638466
NCBI Gene ID:5606
NCBI Accession:P46734.2
UniProt Secondary Accession:P46734,Q99441, Q9UE71, Q9UE72, B3KSK7,
UniProt Related Accession:P46734
Molecular Weight:39,940 Da
NCBI Full Name:Dual specificity mitogen-activated protein kinase kinase 3
NCBI Synonym Full Names:mitogen-activated protein kinase kinase 3
NCBI Official Symbol:MAP2K3  
NCBI Official Synonym Symbols:MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2  
NCBI Protein Information:dual specificity mitogen-activated protein kinase kinase 3
UniProt Protein Name:Dual specificity mitogen-activated protein kinase kinase 3
UniProt Synonym Protein Names:MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2
Protein Family:Dual specificity mitogen-activated protein kinase kinase
UniProt Gene Name:MAP2K3  
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