Human MAGEA5 Recombinant Protein (RPPB3912)

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SKU:
RPPB3912
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MAGEA5
Synonyms:
Melanoma antigen family A 5
Synonyms:
Cancer/testis antigen 15
Synonyms:
CT15
Synonyms:
cancer/testis antigen family 1 member 5
Source:
Escherichia Coli
Uniprot:
P43359
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Description

Product Name:Human MAGEA5 Recombinant Protein
Product Code:RPPB3912
Size:10µg
Species:Human
Target:MAGEA5
Synonyms:Melanoma antigen family A 5, Cancer/testis antigen 1.5, CT1.5, cancer/testis antigen family 1 member 5, MAGE-5 (5a/5b) antigen, MAGEA4, MGC129526.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MAGEA5 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1mM PMSF and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSLEQK SQHCKPEEGL DTQEEALGLV GVQAATTEEQ EAVSSSSPLV PGTLGEVPAA GSPGPLKSPQ GASAIPTAID FTLWRQSIKG SSNQEEEGPS TSPDPESVFR AALSKKVADL IHFLLLKY

MAGEA5 belongs to the MAGEA gene family which encodes proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes are variable, which signify that the presence of this gene family enables the same role to be expressed under diverse transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They are associated with several hereditary disorders, like dyskeratosis congenita. MAGEA5 gene encodes a protein which is C-terminally truncated compared to other family members, and can be alternatively interpreted to be a pseudogene.

MAGEA5 Human Recombinant produced in E. coli is a single polypeptide chain containing 148 amino acids (1-124) and having a molecular mass of 15.6kDa.MAGEA5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011]
UniProt Code:P43359
NCBI GenInfo Identifier:80478226
NCBI Gene ID:4104
NCBI Accession:BC109187
UniProt Secondary Accession:P43359
UniProt Related Accession:P43359
Molecular Weight:
NCBI Full Name:Homo sapiens melanoma antigen family A, 5, mRNA
NCBI Synonym Full Names:MAGE family member A5
NCBI Official Symbol:MAGEA5  
NCBI Official Synonym Symbols:CT1.5; MAGE5; MAGEA4  
NCBI Protein Information:melanoma-associated antigen 5
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