Human LZTFL1 Recombinant Protein (RPPB3899)

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SKU:
RPPB3899
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
LZTFL1
Synonyms:
Leucine Zipper Transcription Factor-Like 1
Synonyms:
BBS17
Synonyms:
LeucineZipper Transcription Factor-Like Protein 1
Synonyms:
Leucine zipper transcriptionfactor-like protein 1
Source:
Escherichia Coli
Uniprot:
Q9NQ48
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Description

Product Name:Human LZTFL1 Recombinant Protein
Product Code:RPPB3899
Size:20µg
Species:Human
Target:LZTFL1
Synonyms:Leucine Zipper Transcription Factor-Like 1, BBS17, LeucineZipper Transcription Factor-Like Protein 1, Leucine zipper transcriptionfactor-like protein 1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:LZTFL1 protein solution (1mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVEDTFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEFEKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEKALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMAEKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED

LeucineZipper Transcription Factor-Like 1, also known as LZTFL1 is a ubiquitouslyexpressed protein which localizes to the cytoplasm. LZTFL1 interacts with Bardet-BiedlSyndrome proteins (BBS) and during its interaction with BBS protein complexes,regulates protein trafficking to the ciliary membrane. Nonsense mutations inLZTFL1 cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized partlyby polydactyly, obesity, cognitive impairment, hypogonadism, and  kidney failure. LZTFL1 also acts as a tumorsuppressor; possibly by interacting with E-cadherin as well as the actin cytoskeletonand in this manner regulating the transition of epithelial cells to mesenchymalcells.

LZTFL1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 322 amino acids (1-299 a.a) and having a molecularmass of 37.0kDa.LZTFL1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
UniProt Code:Q9NQ48
NCBI GenInfo Identifier:74734310
NCBI Gene ID:54585
NCBI Accession:Q9NQ48.1
UniProt Secondary Accession:Q9NQ48,Q8TC61, Q9NQ56, B3KSI9, B4E0K7
UniProt Related Accession:Q9NQ48
Molecular Weight:29,332 Da
NCBI Full Name:Leucine zipper transcription factor-like protein 1
NCBI Synonym Full Names:leucine zipper transcription factor like 1
NCBI Official Symbol:LZTFL1  
NCBI Official Synonym Symbols:BBS17  
NCBI Protein Information:leucine zipper transcription factor-like protein 1
UniProt Protein Name:Leucine zipper transcription factor-like protein 1
UniProt Synonym Protein Names:
Protein Family:Leucine zipper transcription factor-like protein
UniProt Gene Name:LZTFL1  
UniProt Entry Name:LZTL1_HUMAN
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