Human LOX Recombinant Protein (RPPB1909)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB1909
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
LOX
Synonyms:
Lysyl Oxidase
Synonyms:
EC 14313
Synonyms:
Protein-lysine 6-oxidase
Synonyms:
Lysyloxidase
Source:
Escherichia Coli
Uniprot:
P28300
€0.00
Frequently bought together:

Description

Product Name:Human LOX Recombinant Protein
Product Code:RPPB1909
Size:20µg
Species:Human
Target:LOX
Synonyms:Lysyl Oxidase, EC 1.4.3.13, Protein-lysine 6-oxidase, Lysyloxidase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LOX protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDLVADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYSWEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCLEDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYILKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY

Lysyl Oxidase also known as LOX is an extracellular copper enzyme which initiates the crosslinking ofcollagens and  elastin. LOX catalyzesoxidative deamination of the epsilon-amino group in certain lysine andhydroxylysine residues of collagens and lysine residues of elastin. Adding upto crosslinking extracellular matrix proteins, LOX plays a part in tumorsuppression. Moreover, defects in LOX are the cause of autosomal recessivecutis laxa type I, CL type I. Two transcript variants encoding dissimilar isoformshave been found for LOX.

LOX Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 272 amino acids (169-417a.a) andhaving a molecular mass of 31.4kDa.LOX is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.
UniProt Protein Details:

Protein type:EC 1.4.3.13; Secreted; Secreted, signal peptide; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: extracellular region

Molecular Function:protein binding

Biological Process: extracellular matrix organization and biogenesis; protein modification process

Disease: Cutis Laxa, Autosomal Recessive, Type Ia

NCBI Summary:This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
UniProt Code:P28300
NCBI GenInfo Identifier:417269
NCBI Gene ID:4015
NCBI Accession:P28300.2
UniProt Secondary Accession:P28300,Q5FWF0, B2R5Q3,
UniProt Related Accession:P28300
Molecular Weight:46,944 Da
NCBI Full Name:Protein-lysine 6-oxidase
NCBI Synonym Full Names:lysyl oxidase
NCBI Official Symbol:LOX  
NCBI Protein Information:protein-lysine 6-oxidase
UniProt Protein Name:Protein-lysine 6-oxidase
UniProt Synonym Protein Names:Lysyl oxidase
Protein Family:Linoleate 9/13-lipoxygenase
UniProt Gene Name:LOX  
UniProt Entry Name:LYOX_HUMAN
View AllClose

Related Products