Human LIN7A Recombinant Protein (RPPB3863)

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SKU:
RPPB3863
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
LIN7A
Synonyms:
Protein lin-7 homolog A
Synonyms:
Lin-7A
Synonyms:
hLin-7
Synonyms:
Mammalian lin-seven protein 1
Source:
Escherichia Coli
Uniprot:
O14910
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Description

Product Name:Human LIN7A Recombinant Protein
Product Code:RPPB3863
Size:10µg
Species:Human
Target:LIN7A
Synonyms:Protein lin-7 homolog A, Lin-7A, hLin-7, Mammalian lin-seven protein 1, MALS-1, Tax interaction protein 33, TIP-33, Vertebrate lin-7 homolog 1, Veli-1, LIN7A, MALS1, VELI1, LIN7.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:LIN7A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLKPSVT SAPTADMATL TVVQPLTLDR DVARAIELLE KLQESGEVPV HKLQSLKKVL QSEFCTAIRE VYQYMHETIT VNGCPEFRAR ATAKATVAAF AASEGHSHPR VVELPKTDEG LGFNVMGGKE QNSPIYISRI IPGGVAERHG GLKRGDQLLS VNGVSVEGEH HEKAVELLKA AKDSVKLVVR YTPKVLEEME ARFEKLRTAR RRQQQQLLIQ QQQQQQQQQT QQNHMS

Lin7A is a member of the lin-7 family. Lin7A is comprised of one L27 domain and one PDZ (DHR) domain. Lin7A plays a part in launching and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Lin7A is expressed in the brain, testis, kidney, placenta and liver.

LIN7A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 256 amino acids (1-233 a.a.) and having a molecular mass of 28.4kDa.LIN7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.
UniProt Protein Details:

Protein type:Cell adhesion; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: basolateral plasma membrane; intercellular junction; plasma membrane

Molecular Function:protein binding

Biological Process: maintenance of epithelial cell polarity; neurotransmitter secretion; protein complex assembly

NCBI Summary:The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]
UniProt Code:O14910
NCBI GenInfo Identifier:59798442
NCBI Gene ID:8825
NCBI Accession:O14910.2
UniProt Secondary Accession:O14910,Q147W1, Q6LES3, Q7LDS4, A4FTY3,
UniProt Related Accession:O14910
Molecular Weight:25,997 Da
NCBI Full Name:Protein lin-7 homolog A
NCBI Synonym Full Names:lin-7 homolog A, crumbs cell polarity complex component
NCBI Official Symbol:LIN7A  
NCBI Official Synonym Symbols:LIN7; VELI1; LIN-7A; MALS-1; TIP-33  
NCBI Protein Information:protein lin-7 homolog A
UniProt Protein Name:Protein lin-7 homolog A
UniProt Synonym Protein Names:Mammalian lin-seven protein 1; MALS-1; Tax interaction protein 33; TIP-33; Vertebrate lin-7 homolog 1; Veli-1
Protein Family:Protein
UniProt Gene Name:LIN7A  
UniProt Entry Name:LIN7A_HUMAN
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