Human LECT2 Recombinant Protein (RPPB3856)

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SKU:
RPPB3856
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
LECT2
Synonyms:
Leukocyte Cell-Derived Chemotaxin 2
Synonyms:
Leukocyte Cell-Derived Chemotaxin-2
Synonyms:
Chondromodulin-II
Synonyms:
Chm-II
Source:
Escherichia Coli
Uniprot:
O14960
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Description

Product Name:Human LECT2 Recombinant Protein
Product Code:RPPB3856
Size:10µg
Species:Human
Target:LECT2
Synonyms:Leukocyte Cell-Derived Chemotaxin 2, Leukocyte Cell-Derived Chemotaxin-2, Chondromodulin-II, Chm-II, LECT-2, HLECT2, Chm2, LECT2.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:LECT2 was filtered (0.4 µm) and lyophilized in 20mM Tris buffer, 50mM NaCl & pH 7.5.
Solubility:It is recommended to add 200µl of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. LECT2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASGPWANICAGK SSNEIRTCDR HGCGQYSAQR SQRPHQGVDI LCSAGSTVYA PFTGMIVGQE KPYQNKNAIN NGVRISGRGF CVKMFYIKPI KYKGPIKKGE KLGTLLPLQK VYPGIQSHVH IENCDSSDPT AYL

Leukocyte Cell-Derived Chemotaxin 2 (LECT2) functions as a chemotactic factor to neutrophils. LECT2 stimulates the proliferation of chondrocytes and osteoblasts. LECT2 is strongly expressed in the liver and weakly in the testis. LECT2 is a secreted, 16kDa protein which serves as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. LECT2 protein has a high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in the LECT2 gene is linked with rheumatoid arthritis.

LECT2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Gly19-Leu151) containing 143 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 16kDa.

UniProt Protein Function:LECT2: Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Belongs to the LECT2/MIM-1 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; extracellular space

Molecular Function:identical protein binding

Biological Process: chemotaxis; skeletal development

NCBI Summary:This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
UniProt Code:O14960
NCBI GenInfo Identifier:59806345
NCBI Gene ID:3950
NCBI Accession:NP_002293.2
UniProt Secondary Accession:O14960,O14565, Q52M49, B2RA90,
UniProt Related Accession:O14960
Molecular Weight:16,390 Da
NCBI Full Name:leukocyte cell-derived chemotaxin-2
NCBI Synonym Full Names:leukocyte cell derived chemotaxin 2
NCBI Official Symbol:LECT2  
NCBI Official Synonym Symbols:chm2; chm-II  
NCBI Protein Information:leukocyte cell-derived chemotaxin-2
UniProt Protein Name:Leukocyte cell-derived chemotaxin-2
Protein Family:Leukocyte cell-derived chemotaxin
UniProt Gene Name:LECT2  
UniProt Entry Name:LECT2_HUMAN
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