Human LCN2 Recombinant Protein (RPPB1889)
- SKU:
- RPPB1889
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- LCN2
- Synonyms:
- Neutrophil gelatinase-associated lipocalin
- NGAL
- p25
- 25 kDa alpha-2-microglobulin-related subunit of MMP-9
- Source:
- Escherichia Coli
- Uniprot:
- P80188
Description
| Product Name: | Human LCN2 Recombinant Protein |
| Product Code: | RPPB1889 |
| Size: | 10µg |
| Species: | Human |
| Target: | LCN2 |
| Synonyms: | Neutrophil gelatinase-associated lipocalin, NGAL, p25, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, LCN2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | Lipocalin-2 is supplied in PBS, 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. Single band on Western Blot. |
Recombinant Human Lipocalin-2 also called Neutrophil Gelatinase Associated Lipocalin (NGAL) belongs to a family of lipocans which include 25 proteins (including a1-microglobulin and b-lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core.They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke.
Neutrophil Gelatinase Associated Lipocalin Human Recombinant is expressed in E. coli having a molecular weight of 28.1 kDa fused to an amino terminal hexahistidine tag.The LCN2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34 Cellular Component: extracellular space; extracellular region; cytosol Molecular Function:protein homodimerization activity; protease binding; transporter activity; iron ion binding Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; siderophore transport; positive regulation of cell projection organization and biogenesis; innate immune response; ion transport; response to herbicide; transmembrane transport |
| UniProt Code: | P80188 |
| NCBI GenInfo Identifier: | 1171700 |
| NCBI Gene ID: | 3934 |
| NCBI Accession: | P80188.2 |
| UniProt Secondary Accession: | P80188,P30150, Q5SYV9, Q5SYW0, Q6FGL5, Q92683, A6NII8 B4DWV4, B7ZAA2, |
| UniProt Related Accession: | P80188 |
| Molecular Weight: | |
| NCBI Full Name: | Neutrophil gelatinase-associated lipocalin |
| NCBI Synonym Full Names: | lipocalin 2 |
| NCBI Official Symbol: | LCN2 |
| NCBI Official Synonym Symbols: | 24p3; MSFI; NGAL |
| NCBI Protein Information: | neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; oncogene 24p3; siderocalin LCN2; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9 |
| UniProt Protein Name: | Neutrophil gelatinase-associated lipocalin |
| UniProt Synonym Protein Names: | 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25 |
| Protein Family: | Neutrophil gelatinase-associated lipocalin |
| UniProt Gene Name: | LCN2 |
| UniProt Entry Name: | NGAL_HUMAN |
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