Human LASP1 Recombinant Protein (RPPB3844)

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SKU:
RPPB3844
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
LASP1
Synonyms:
LIM and SH3 protein 1
Synonyms:
MLN50
Synonyms:
Lasp-1
Synonyms:
Metastatic lymph node gene 50 protein
Source:
Escherichia Coli
Uniprot:
Q14847
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Description

Product Name:Human LASP1 Recombinant Protein
Product Code:RPPB3844
Size:5µg
Species:Human
Target:LASP1
Synonyms:LIM and SH3 protein 1, MLN50, Lasp-1, Metastatic lymph node gene 50 protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LASP1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMNPNCA RCGKIVYPTE KVNCLDKFWH KACFHCETCK MTLNMKNYKG YEKKPYCNAH YPKQSFTMVA DTPENLRLKQ QSELQSQVRY KEEFEKNKGK GFSVVADTPE LQRIKKTQDQ ISNIKYHEEF EKSRMGPSGG EGMEPERRDS QDGSSYRRPL EQQQPHHIPT SAPVYQQPQQ QPVAQSYGGY KEPAAPVSIQ RSAPGGGGKR YRAVYDYSAA DEDEVSFQDG DTIVNVQQID DGWMYGTVER TGDTGMLPAN YVEAI

LASP1 has a vital part in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation can additionally assist in regulation of actin-associated ion transport activities in the parietal cell and in several other F-actin-rich secretory epithelial cell types.

LASP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 285 amino acids (1-261) and having a molecular mass of 32.3kDa.LASP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 17q11-q21.3

Cellular Component: cortical actin cytoskeleton; focal adhesion

Molecular Function:actin filament binding; ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity; zinc ion binding

Biological Process: ion transport; positive regulation of signal transduction

NCBI Summary:This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
UniProt Code:Q14847
NCBI GenInfo Identifier:3122342
NCBI Gene ID:3927
NCBI Accession:Q14847.2
UniProt Secondary Accession:Q14847,Q96ED2, Q96IG0, B4DGQ0,
UniProt Related Accession:Q14847
Molecular Weight:23,181 Da
NCBI Full Name:LIM and SH3 domain protein 1
NCBI Synonym Full Names:LIM and SH3 protein 1
NCBI Official Symbol:LASP1  
NCBI Official Synonym Symbols:MLN50; Lasp-1  
NCBI Protein Information:LIM and SH3 domain protein 1
UniProt Protein Name:LIM and SH3 domain protein 1
UniProt Synonym Protein Names:Metastatic lymph node gene 50 protein; MLN 50
Protein Family:LIM and SH3 domain protein
UniProt Gene Name:LASP1  
UniProt Entry Name:LASP1_HUMAN
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