Human KLF12 Recombinant Protein (RPPB3798)

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SKU:
RPPB3798
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
KLF12
Synonyms:
AP-2rep
Synonyms:
AP2REP
Synonyms:
HSPC122
Synonyms:
Krueppel-like factor 12
Source:
Escherichia Coli
Uniprot:
Q9Y4X4
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Description

Product Name:Human KLF12 Recombinant Protein
Product Code:RPPB3798
Size:20µg
Species:Human
Target:KLF12
Synonyms:AP-2rep, AP2REP, HSPC122, Krueppel-like factor 12, Transcriptionalrepressor AP-2rep.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:KLF12 protein solution (0.5mg/ml) contains 20mM Tris-HClbuffer, (pH8.0) ,10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNIHMKR KTIKNINTFE NRMLMLDGMP AVRVKTELLE SEQGSPNVHNYPDMEAVPLL LNNVKGEPPE DSLSVDHFQT QTEPVDLSIN KARTSPTAVS SSPVSMTASA SSPSSTSTSSSSSSRLASSP TVITSVSSAS SSSTVLTPGP LVASASGVGG QQFLHIIHPV PPSSPMNLQS NKLSHVHRIP VVVQSVPVVY TAVRSPGNVNNTIVVPLLED GRGHGKAQMD PRGLSPRQSK SDSDDDDLPN VTLDSVNETG STALSIARAV QEVHPSPVSRVRGNRMNNQK FPCSISPFSI ESTRRQRRSE SPDSRKRRIH RCDFEGCNKV YTKSSHLKAH RRTHTGEKPY KCTWEGCTWK FARSDELTRH YRKHTGVKPF KCADCDRSFSRSDHLALHRR RHMLV

Krueppel-like factor 12 (KLF12) belongs to the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a particular site in the AP-2 alpha gene promoter. AP-2 alpha (Activator protein-2 alpha) is a developmentally-regulated transcription factor and vital regulator of gene expression during vertebrate development and carcinogenesis. KLF12 gene repression entails binding with a corepressor, CtBP1.

KLF12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 425 amino acids (1-402 a.a) and having a molecular mass of 46.6kDa.KLF12 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLF12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; C2H2-type zinc finger protein; DNA-bindingChromosomal Location of Human Ortholog: 13q22Cellular Component: nucleusMolecular Function: DNA binding; metal ion binding; transcription corepressor activity; transcription factor activityBiological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y4X4
NCBI GenInfo Identifier:91771555
NCBI Gene ID:11278
NCBI Accession:Q9Y4X4.2
UniProt Secondary Accession:Q9Y4X4,Q5VZM7, Q9UHZ0, A8K5T2, L0R3J4
UniProt Related Accession:Q9Y4X4
Molecular Weight:402
NCBI Full Name:Krueppel-like factor 12
NCBI Synonym Full Names:Kruppel-like factor 12
NCBI Official Symbol:KLF12  
NCBI Official Synonym Symbols:AP2REP; AP-2rep; HSPC122  
NCBI Protein Information:Krueppel-like factor 12; AP-2 repressor; AP-2rep transcription factor; transcriptional repressor AP-2rep; KLF12 zinc finger transcriptional repressor
UniProt Protein Name:Krueppel-like factor 12
UniProt Synonym Protein Names:Transcriptional repressor AP-2rep
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF12  
UniProt Entry Name:KLF12_HUMAN
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