Human KIR2DL4 Recombinant Protein (RPPB3790)

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SKU:
RPPB3790
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
KIR2DL4
Synonyms:
Killer Cell Immunoglobulin Like Receptor
Synonyms:
Two Ig Domains And Long Cytoplasmic Tail 4
Synonyms:
Killer Cell Immunoglobulin-Like Receptor
Synonyms:
Two Domains
Source:
Sf9 Insect cells
Uniprot:
Q99706
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Description

Product Name:Human KIR2DL4 Recombinant Protein
Product Code:RPPB3790
Size:5µg
Species:Human
Target:KIR2DL4
Synonyms:Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4,Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail 4,Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS,CD158 Antigen-Like Family Member D, KIR-103AS, KIR103AS, CD158D, G9P, Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158d Antigen, KIR-2DL4, KIR103, KIR2DL4.  
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KIR2DL4 protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:HVGGQDKPFC SAWPSAVVPQ GGHVTLRCHY RRGFNIFTLY KKDGVPVPEL YNRIFWNSFL ISPVTPAHAG TYRCRGFHPH SPTEWSAPSN PLVIMVTGLY EKPSLTARPG PTVRAGENVT LSCSSQSSFD IYHLSREGEA HELRLPAVPS INGTFQADFP LGPATHGETY RCFGSFHGSPYEWSDPSDPL PVSVTGNPSS SWPSPTEPSF KTGIARHLHL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSRDELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH

Killer cell immunoglobulin-like receptor 2DL4, also known as KIR2DL4 is part of the killer cell Ig-like receptor (KIR) family. KIR proteins with the long cytoplasmic domain transduce inhibitory signals through an immune tyrosine-based inhibitory motif (ITIM), whereas KIR proteins which contain the short cytoplasmic domain, lack the ITIM motif and as a substitute associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DL4 stimulates NK cells to produce IFN-gamma and stimulation with IL-2 upregulates cell surface expression on CD56dimcells and leads to the inhibition of the cytolytic NK cell function.

KIR2DL4 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 458 amino acids (24-242 a.a.) and having a molecular mass of 51kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). KIR2DL4 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques. 

UniProt Protein Function:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
NCBI Summary:Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
UniProt Code:Q99706
NCBI GenInfo Identifier:325511396
NCBI Gene ID:3805
NCBI Accession:Q99706.3
UniProt Secondary Accession:Q99706,O14621, O14622, O14623, O14624, O43534, P78400 P78401, Q8N738, Q99559, Q99560, A8W795,
UniProt Related Accession:Q99706
Molecular Weight:24,917 Da
NCBI Full Name:Killer cell immunoglobulin-like receptor 2DL4
NCBI Synonym Full Names:killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
NCBI Official Symbol:KIR2DL4  
NCBI Official Synonym Symbols:G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS  
NCBI Protein Information:killer cell immunoglobulin-like receptor 2DL4
UniProt Protein Name:Killer cell immunoglobulin-like receptor 2DL4
UniProt Synonym Protein Names:CD158 antigen-like family member D; G9P; Killer cell inhibitory receptor 103AS; KIR-103AS; MHC class I NK cell receptor KIR103AS; CD_antigen: CD158d
Protein Family:Killer cell immunoglobulin-like receptor
UniProt Gene Name:KIR2DL4  
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