Human IMPA2 Recombinant Protein (RPPB1849)

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SKU:
RPPB1849
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
IMPA2
Synonyms:
Inositol monophosphatase 2
Synonyms:
IMP 2
Synonyms:
IMPase 2
Synonyms:
Inositol-1(or 4)-monophosphatase 2
Source:
Escherichia Coli
Uniprot:
O14732
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Description

Product Name:Human IMPA2 Recombinant Protein
Product Code:RPPB1849
Size:10µg
Species:Human
Target:IMPA2
Synonyms:Inositol monophosphatase 2, IMP 2, IMPase 2, Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2, IMPA2, IMP.18P.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IMPA2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer(pH 8.0), 10% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK

IMPA2 is a member of the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate and has a significant role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li(+) action in brain. IMPA2 is considered to have a role in schizophrenia and bipolar disorder.

IMPA2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 308 amino acids (1-288 a.a.) and having a molecular mass of 33.5kDa. The IMPA2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IMPA2: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; Motility/polarity/chemotaxis; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 18p11.21

Cellular Component: cytoplasm; cytosol

Molecular Function:inositol-1(or 4)-monophosphatase activity; protein binding; protein homodimerization activity

Biological Process: inositol metabolic process; inositol phosphate dephosphorylation; inositol phosphate metabolic process; phosphate metabolic process; signal transduction

NCBI Summary:This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
UniProt Code:O14732
NCBI GenInfo Identifier:3914095
NCBI Gene ID:3613
NCBI Accession:O14732.1
UniProt Secondary Accession:O14732,Q9UJT3, B0YJ29,
UniProt Related Accession:O14732
Molecular Weight:31kDa
NCBI Full Name:Inositol monophosphatase 2
NCBI Synonym Full Names:inositol monophosphatase 2
NCBI Official Symbol:IMPA2  
NCBI Protein Information:inositol monophosphatase 2
UniProt Protein Name:Inositol monophosphatase 2
UniProt Synonym Protein Names:Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2
UniProt Gene Name:IMPA2  
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