Human IL22 Recombinant Protein (RPPB0638)

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SKU:
RPPB0638
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
IL22
Synonyms:
IL-TIF
Synonyms:
TIFa
Synonyms:
IL-10-related T-cell-derived-inducible factor
Synonyms:
IL-22
Source:
Sf9 Insect cells
Uniprot:
Q9GZX6
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Description

Product Name:Human IL22 Recombinant Protein
Product Code:RPPB0638
Size:5µg
Species:Human
Target:IL22
Synonyms:IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL22 protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPAPISSHC RLDKSNFQQP YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACIH HHHHH
Biological Activity:The ED50 as determined by its ability to induce IL-10 secretion using COLO 205 human colorectal adenocarcinoma cell is ? 1.2 ng/ml.

Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acids signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10, respectively. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses.

IL22 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (34-179 a.a.)  fused to a 9 aa His Tag at C-terminus containing a total of 155 amino acids and having a molecular mass of 17.8kDa.IL22 shows multiple bands between 18-28kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function:interleukin-22 receptor binding; cytokine activity

Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response

UniProt Code:Q9GZX6
NCBI GenInfo Identifier:17366814
NCBI Gene ID:50616
NCBI Accession:Q9GZX6.1
UniProt Related Accession:Q9GZX6
Molecular Weight:Calculated MW: 20kDaObserved MW: Refer to figures
NCBI Full Name:Interleukin-22
NCBI Synonym Full Names:interleukin 22
NCBI Official Symbol:IL22  
NCBI Official Synonym Symbols:TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23  
NCBI Protein Information:interleukin-22; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor
UniProt Protein Name:Interleukin-22
UniProt Synonym Protein Names:Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF
Protein Family:Interleukin
UniProt Gene Name:IL22  
UniProt Entry Name:IL22_HUMAN
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