MTSS1 (Metastasis suppressor 1); also known as Missing in metastasis (MIM); is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development; carcinogenesis and metastasis.
Product Name:
Human IL17BR/IL17RB Recombinant Protein (RPES1249)
Product Code:
RPES1249
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
CRL4,EVI27,IL17BR,IL17RH1
Accession:
NP_061195.2
Sequence:
Met 1-Gly289
Fusion tag:
C-His
Activity:
Measured by its binding ability in a functional ELISA.Immobilized human IL17BR-His at 10 µg/ml (100 ?l/well) can bind human Fc-IL25 ; The EC50 of human Fc-IL25 is 0.1-0.3 µg/ml.
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with a C-terminal polyhistidine tag.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
31.5 kDa
AP Mol Mass:
41-45 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
