Human IER3 Recombinant Protein (RPPB3735)

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SKU:
RPPB3735
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
IER3
Synonyms:
immediate early response 3
Synonyms:
DIF-2
Synonyms:
DIF2
Synonyms:
GLY96
Source:
Escherichia Coli
Uniprot:
P46695
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Description

Product Name:Human IER3 Recombinant Protein
Product Code:RPPB3735
Size:10µg
Species:Human
Target:IER3
Synonyms:immediate early response 3, DIF-2, DIF2, GLY96, IEX-1,IEX-1L, IEX1, PRG1, Protein DIF-2, Immediate early protein GLY96, PACAP-responsive gene 1protein, Differentiation-dependent gene 2 protein, IER3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:IER3 protein solution (0.25mg/ml) contains 20mM Tris-HClbuffer, (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMCHSRSC HPTMTILQAP TPAPSTIPGP RRGSGPEIFT FDPLPEPAAAPAGRPSASRG HRKRSRRVLY PRVVRRQLPV EEPNP

Immediate Early Response 3 (IER3) functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. IER3 has a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. In addition, IER3 serves as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, IER3 provides pancreatic ductal adenocarcinoma with significant resistance to cell stress, such as starvation.

IER3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 105 amino acids (1-82 a.a.) and having a molecular mass of 11.4kDa.IER3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IEX-1: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. Belongs to the IER3 family.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol; nucleus

Molecular Function:protein binding

Biological Process: anatomical structure morphogenesis; apoptosis; regulation of phosphoinositide 3-kinase cascade

NCBI Summary:This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
UniProt Code:P46695
NCBI GenInfo Identifier:317373569
NCBI Gene ID:8870
NCBI Accession:P46695.4
UniProt Secondary Accession:P46695,Q5SU30, Q92691, Q93044,
UniProt Related Accession:P46695
Molecular Weight:16,903 Da
NCBI Full Name:Radiation-inducible immediate-early gene IEX-1
NCBI Synonym Full Names:immediate early response 3
NCBI Official Symbol:IER3  
NCBI Official Synonym Symbols:DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L  
NCBI Protein Information:radiation-inducible immediate-early gene IEX-1
UniProt Protein Name:Radiation-inducible immediate-early gene IEX-1
UniProt Synonym Protein Names:Differentiation-dependent gene 2 protein; Protein DIF-2; Immediate early protein GLY96; Immediate early response 3 protein; PACAP-responsive gene 1 protein; Protein PRG1
Protein Family:Radiation-inducible immediate-early gene
UniProt Gene Name:IER3  
UniProt Entry Name:IEX1_HUMAN
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