Human HTATIP2 Recombinant Protein (RPPB1836)
- SKU:
- RPPB1836
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- HTATIP2
- Synonyms:
- TIP30
- CC3
- SDR44U1
- HTATIP2
- Source:
- Escherichia Coli
- Uniprot:
- Q9BUP3
Description
| Product Name: | Human HTATIP2 Recombinant Protein |
| Product Code: | RPPB1836 |
| Size: | 20µg |
| Species: | Human |
| Target: | HTATIP2 |
| Synonyms: | TIP30, CC3, SDR44U1, HTATIP2, EC=1.1.1.-, HIV-1 TAT-interactive protein 2, FLJ26963. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | HTATIP2 protein solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP |
HTATIP2 is part of the short-chain dehydrogenases/reductases (SDR) family which acts as a tumor suppressor in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 cooperates with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in HTATIP2 are related with hepatocellular carcinomas and apoptotic resistant tumor cells, implicating a probable use for HTATIP2 in antitumor therapy.
HTATIP2 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-242 a.a.) and having a molecular mass of 29.3 kDa. The HTATIP2 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.- Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis |
| UniProt Code: | Q9BUP3 |
| NCBI GenInfo Identifier: | 317373366 |
| NCBI Gene ID: | 10553 |
| NCBI Accession: | Q9BUP3.2 |
| UniProt Secondary Accession: | Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8, |
| UniProt Related Accession: | Q9BUP3 |
| Molecular Weight: | 242 |
| NCBI Full Name: | Oxidoreductase HTATIP2 |
| NCBI Synonym Full Names: | HIV-1 Tat interactive protein 2, 30kDa |
| NCBI Official Symbol: | HTATIP2 |
| NCBI Official Synonym Symbols: | CC3; TIP30; SDR44U1 |
| NCBI Protein Information: | oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1 |
| UniProt Protein Name: | Oxidoreductase HTATIP2 |
| UniProt Synonym Protein Names: | 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 |
| Protein Family: | Oxidoreductase |
| UniProt Gene Name: | HTATIP2 |
| UniProt Entry Name: | HTAI2_HUMAN |
Related Products
