Human HSD17B1 Recombinant Protein (RPPB1832)
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주문- SKU:
- RPPB1832
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- HSD17B1
- Synonyms:
- E2 17-beta-dehydrogenase 1
- Synonyms:
- EC 11162
- Synonyms:
- 17-beta-hydroxysteroid dehydrogenase type 1
- Synonyms:
- 17-beta-HSD 1
- Source:
- Escherichia Coli
- Uniprot:
- P14061
Description
| Product Name: | Human HSD17B1 Recombinant Protein |
| Product Code: | RPPB1832 |
| Size: | 10µg |
| Species: | Human |
| Target: | HSD17B1 |
| Synonyms: | E2 17-beta-dehydrogenase 1, EC 1.1.1.62, 17-beta-hydroxysteroid dehydrogenase type 1, 17-beta-HSD 1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, E2DH, Placental 17-beta-hydroxysteroid dehydrogenase, HSD17B1, E17KSR, EDH17B1, EDH17B2, EDHB17, HSD17, SDR28C1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | HSD17B1 solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMARTVV LITGCSSGIG LHLAVRLASD PSQSFKVYAT LRDLKTQGRL WEAARALACP PGSLETLQLD VRDSKSVAAA RERVTEGRVD VLVCNAGLGL LGPLEALGED AVASVLDVNV VGTVRMLQAF LPDMKRRGSG RVLVTGSVGG LMGLPFNDVY CASKFALEGL CESLAVLLLP FGVHLSLIEC GPVHTAFMEK VLGSPEEVLD RTDIHTFHRF YQYLAHSKQV FREAAQNPEE VAEVFLTALR APKPTLRYFT TERFLPLLRM RLDDPSGSNY VTAMHREVFG DVPAKAEAGA EAGGGAGPGA EDEAGRGAVG DPELGDPPAA PQ |
E2 17-beta-dehydrogenase 1 (HSD17B1) is a member of the short-chain dehydrogenases/reductases (SDR) family. The HSD17B1 protein advances the reduction of estrogens and androgens. In addition, the HSD17B1 has a 20-alpha-HSD activity. HSD17B1 preferentially uses NADH.
HSD17B1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 352 amino acids (1-328 a.a) and having a molecular mass of 37.5kDa.HSD17B1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HSD17B1: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Oxidoreductase Chromosomal Location of Human Ortholog: 17q11-q21 Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; cytosol Molecular Function:estradiol 17-beta-dehydrogenase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity Biological Process: steroid metabolic process; estrogen metabolic process; steroid biosynthetic process; estrogen biosynthetic process |
| UniProt Code: | P14061 |
| NCBI GenInfo Identifier: | 313104233 |
| NCBI Gene ID: | 3292 |
| NCBI Accession: | P14061.3 |
| UniProt Secondary Accession: | P14061,Q2M2L8, B3KXS1, |
| UniProt Related Accession: | P14061 |
| Molecular Weight: | 34,950 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 1 |
| NCBI Synonym Full Names: | hydroxysteroid (17-beta) dehydrogenase 1 |
| NCBI Official Symbol: | HSD17B1 |
| NCBI Official Synonym Symbols: | HSD17; EDHB17; EDH17B2; SDR28C1 |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 1 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Placental 17-beta-hydroxysteroid dehydrogenase |
| Protein Family: | Estradiol 17-beta-dehydrogenase |
| UniProt Gene Name: | HSD17B1 |
| UniProt Entry Name: | DHB1_HUMAN |
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