Human HINT1 Recombinant Protein (RPPB3683)

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SKU:
RPPB3683
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
HINT1
Synonyms:
HINT
Synonyms:
PKCI-1
Synonyms:
PRKCNH1
Synonyms:
FLJ30414
Source:
Escherichia Coli
Uniprot:
P49773
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Description

Product Name:Human HINT1 Recombinant Protein
Product Code:RPPB3683
Size:20µg
Species:Human
Target:HINT1
Synonyms:HINT, PKCI-1, PRKCNH1, FLJ30414, FLJ32340, HINT1, Histidine triad nucleotide-binding protein 1, Adenosine 5'-monophosphoramidase, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, PKCI1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HINT1 solution contains 20mM Tris pH-8 & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG

HINT1 hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Though it was initially considered to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known.

HINT1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 126 amino acids (1-126 a.a.) and having a molecular mass of 13.8 kDa.The HINT1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:HINT1: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha- acetyl lysine methyl ester and AMP-NH2. Belongs to the HINT family.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.-.-.-; Cytoskeletal

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoskeleton; histone deacetylase complex; cytoplasm; plasma membrane; nucleus

Molecular Function:protein kinase C binding; hydrolase activity; nucleotide binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; purine ribonucleotide catabolic process; signal transduction

Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive

NCBI Summary:The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:P49773
NCBI GenInfo Identifier:1708543
NCBI Gene ID:3094
NCBI Accession:P49773.2
UniProt Secondary Accession:P49773,Q9H5W8,
UniProt Related Accession:P49773
Molecular Weight:126
NCBI Full Name:Histidine triad nucleotide-binding protein 1
NCBI Synonym Full Names:histidine triad nucleotide binding protein 1
NCBI Official Symbol:HINT1  
NCBI Official Synonym Symbols:HINT; NMAN; PKCI-1; PRKCNH1  
NCBI Protein Information:histidine triad nucleotide-binding protein 1; protein kinase C inhibitor 1; adenosine 5'-monophosphoramidase; protein kinase C-interacting protein 1
UniProt Protein Name:Histidine triad nucleotide-binding protein 1
UniProt Synonym Protein Names:Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1
Protein Family:Adenylylsulfatase
UniProt Gene Name:HINT1  
UniProt Entry Name:HINT1_HUMAN
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