Human HHEX Recombinant Protein (RPPB3678)

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SKU:
RPPB3678
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HHEX
Synonyms:
Hematopoietically Expressed Homeobox
Synonyms:
Hematopoietically-Expressed Homeobox Protein HHEX
Synonyms:
Homeobox Hematopoietically Expressed
Synonyms:
Proline-Rich Homeodomain-Containing Transcription Factor
Source:
Escherichia Coli
Uniprot:
Q03014
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Description

Product Name:Human HHEX Recombinant Protein
Product Code:RPPB3678
Size:10µg
Species:Human
Target:HHEX
Synonyms:Hematopoietically Expressed Homeobox, Hematopoietically-Expressed Homeobox Protein HHEX, Homeobox Hematopoietically Expressed, Proline-Rich Homeodomain-Containing Transcription Factor, Homeobox Protein PRH, Homeobox Protein HEX, HOX11L-PEN, PRHX, HMPH, PRH, HEX.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HHEX solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMQYPHPG PAAGAVGVPL YAPTPLLQPA HPTPFYIEDI LGRGPAAPTP APTLPSPNSS FTSLVSPYRT PVYEPTPIHP AFSHHSAAAL AAAYGPGGFG GPLYPFPRTV NDYTHALLRH DPLGKPLLWS PFLQRPLHKR KGGQVRFSND QTIELEKKFE TQKYLSPPER KRLAKMLQLS ERQVKTWFQN RRAKWRRLKQ ENPQSNKKEE LESLDSSCDQ RQDLPSEQNK GASLDSSQCS PSPASQEDLE SEISEDSDQE VDIEGDKSYF NAG

The homeobox protein family of transcription factors has many members that take part in developmental processes such as HHEX. HHEX is known to interact with Promyelocytic leukemia protein and expression in specific hematopoietic lines indicates that this protein is involved in hematopoietic differentiation.

HHEX Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 293 amino acids (1-270) and having a molecular mass of 32.0kDa.HHEX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HHEX: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 10q23.33Cellular Component: cytoplasm; nucleusMolecular Function: DNA bending activity; eukaryotic initiation factor 4E binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; TATA-binding protein binding; transcription factor bindingBiological Process: anterior/posterior pattern formation; B cell differentiation; cell differentiation; cell proliferation; mRNA export from nucleus; negative regulation of angiogenesis; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vascular endothelial growth factor receptor signaling pathway; poly(A)+ mRNA export from nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
UniProt Code:Q03014
NCBI GenInfo Identifier:547658
NCBI Gene ID:3087
NCBI Accession:Q03014.1
UniProt Secondary Accession:Q03014,Q96CE9, B1AQ17
UniProt Related Accession:Q03014
Molecular Weight:30,022 Da
NCBI Full Name:Hematopoietically-expressed homeobox protein HHEX
NCBI Synonym Full Names:hematopoietically expressed homeobox
NCBI Official Symbol:HHEX  
NCBI Official Synonym Symbols:HEX; PRH; HMPH; PRHX; HOX11L-PEN  
NCBI Protein Information:hematopoietically-expressed homeobox protein HHEX
UniProt Protein Name:Hematopoietically-expressed homeobox protein HHEX
UniProt Synonym Protein Names:Homeobox protein PRH
Protein Family:Hematopoietically-expressed homeobox protein
UniProt Gene Name:HHEX  
UniProt Entry Name:HHEX_HUMAN
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