Human HERPUD1 Recombinant Protein (RPPB3673)

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SKU:
RPPB3673
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HERPUD1
Synonyms:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Synonyms:
HERPUD1
Synonyms:
Methyl methanesulfonate (MMF)-inducible fragment protein 1
Synonyms:
HERP
Source:
Escherichia Coli
Uniprot:
Q15011
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Description

Product Name:Human HERPUD1 Recombinant Protein
Product Code:RPPB3673
Size:10µg
Species:Human
Target:HERPUD1
Synonyms:Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, HERPUD1, Methyl methanesulfonate (MMF)-inducible fragment protein 1, HERP, KIAA0025, MIF1, Mif1, SUP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The HERPUD1 solution (0.5mg/1ml) contains Phosphate buffer saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMESETEP EPVTLLVKSP NQRHRDLELS GDRGWSVGHL KAHLSRVYPE RPRPEDQRLI YSGKLLLDHQ CLRDLLPKQE KRHVLHLVCN VKSPSKMPEI NAKVAESTEE PAGSNRGQYP EDSSSDGLRQ REVLRNLSSP GWENISRPEA AQQAFQGLGP GFSGYTPYGW LQLSWFQQIY ARQYYMQYLA ATAASGAFVP PPSAQEIPVV SAPAPAPIHN QFPAENQPAN QNAAPQVVVN PGANQNLRMN AQGGPIVEED DEINRD

HERPUD1is a multi-pass membrane protein which is a part of the endoplasmic reticulumquality control system. HERPUD1 owns 1 N-terminal ubiquitin-like domain and isexpressed highly in the brain. HERPUD1 is also known as ER-associateddegradation (ERAD) which takes part in ubiquitin-dependent degradation ofmisfolded endoplasmic reticulum proteins.

HERPUD1 Human Recombinant produced in E. coli is a single polypeptide chain containing 286 amino acids (1-263) and having a molecular mass of 31.6kDa.HERPUD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HERPUD1: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum

Biological Process: ubiquitin-dependent protein catabolic process; endoplasmic reticulum calcium ion homeostasis; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; positive regulation of protein binding; regulation of protein ubiquitination; unfolded protein response; negative regulation of caspase activity; response to unfolded protein

NCBI Summary:The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]
UniProt Code:Q15011
NCBI GenInfo Identifier:3123034
NCBI Gene ID:9709
NCBI Accession:Q15011.1
UniProt Secondary Accession:Q15011,O60644, Q6IAN8, Q96D92, E9PGD1,
UniProt Related Accession:Q15011
Molecular Weight:391
NCBI Full Name:Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
NCBI Synonym Full Names:homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
NCBI Official Symbol:HERPUD1  
NCBI Official Synonym Symbols:SUP; HERP; Mif1  
NCBI Protein Information:homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; MMS-inducible; methyl methanesulfonate (MMF)-inducible fragment protein 1; homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein
UniProt Protein Name:Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
UniProt Synonym Protein Names:Methyl methanesulfonate (MMF)-inducible fragment protein 1
Protein Family:Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
UniProt Gene Name:HERPUD1  
UniProt Entry Name:HERP1_HUMAN
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