Human GIMAP5 Recombinant Protein (RPPB5886)

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SKU:
RPPB5886
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
GIMAP5
Synonyms:
GTPase IMAP family member 5
Synonyms:
Immunity-associated nucleotide 4-like 1 protein
Synonyms:
Immunity-associated nucleotide 5 protein
Synonyms:
IAN-5
Source:
Escherichia Coli
Uniprot:
Q96F15
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Description

Product Name:Human GIMAP5 Recombinant Protein
Product Code:RPPB5886
Size:10µg
Species:Human
Target:GIMAP5
Synonyms:GTPase IMAP family member 5, Immunity-associated nucleotide 4-like 1 protein, Immunity-associated nucleotide 5 protein, IAN-5, hIAN5, Immunity-associated protein 3, GIMAP5, IAN4L1, IAN5, IMAP3, HIMAP3, IAN4, IROD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GIMAP5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGGFQRG KYGTMAEGRS EDNLSATPPA LRIILVGKTG CGKSATGNSI LGQPVFESKL RAQSVTRTCQ VKTGTWNGRK VLVVDTPSIF ESQADTQELY KNIGDCYLLS APGPHVLLLV IQLGRFTAQD TVAIRKVKEV FGTGAMRHVV ILFTHKEDLG GQALDDYVAN TDNCSLKDLV RECERRYCAF NNWGSVEEQR QQQAELLAVI ERLGREREGS FHSNDLFLDA QLLQRTGAGA CQEDYRQYQA KVEWQVEKHK QELRENESNW AYKALLRVKH LMLLHYE

GTPase, IMAP Family Member 5 (GIMAP5) is a part of the GTP-binding superfamily and the immuno-associated nucleotide subfamily of nucleotide-binding proteins. GIMAP5 is an antiapoptotic protein which is required for mitochondrial integrity and T-cell survival. Polymorphisms in GIMAP5 are related with systemic lupus erythematosus. Read-through transcription can be found between GIMAP5 and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. GIMAP5 also contributes to T-cell quiescence.

GIMAP5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284) and having a molecular mass of 34.4 kDa.GIMAP5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GIMAP5: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence. Belongs to the IAN GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Apoptosis; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: mitochondrial outer membrane; lysosome; integral to membrane

Molecular Function:GTP binding

NCBI Summary:This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96F15
NCBI GenInfo Identifier:28416949
NCBI Gene ID:55340
NCBI Accession:NP_060854.2
UniProt Secondary Accession:Q96F15,Q6IA75, Q96NE4, Q9NUK9, D3DWZ5,
UniProt Related Accession:Q96F15
Molecular Weight:34,846 Da
NCBI Full Name:GTPase IMAP family member 5
NCBI Synonym Full Names:GTPase, IMAP family member 5
NCBI Official Symbol:GIMAP5  
NCBI Official Synonym Symbols:IAN4; IAN5; IROD; IAN-5; IMAP3; HIMAP3; IAN4L1  
NCBI Protein Information:GTPase IMAP family member 5; immunity associated protein 3; immune associated nucleotide 4 like 1; immunity-associated nucleotide 5 protein; inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
UniProt Protein Name:GTPase IMAP family member 5
UniProt Synonym Protein Names:Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3
Protein Family:GTPase IMAP family
UniProt Gene Name:GIMAP5  
UniProt Entry Name:GIMA5_HUMAN
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