Human EIF1AY Recombinant Protein (RPPB3421)
- SKU:
- RPPB3421
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- EIF1AY
- Synonyms:
- Eukaryotic translation initiation factor 1A Y chromosome
- Eukaryotic translation initiation factor 4C
- eIF-4C
- eIF-1A Y isoform
- Source:
- Escherichia Coli
- Uniprot:
- O14602
Description
| Product Name: | Human EIF1AY Recombinant Protein |
| Product Code: | RPPB3421 |
| Size: | 10µg |
| Species: | Human |
| Target: | EIF1AY |
| Synonyms: | Eukaryotic translation initiation factor 1A Y chromosome, Eukaryotic translation initiation factor 4C, eIF-4C, eIF-1A Y isoform. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The EIF1AY protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPKNKGK GGKNRRRGKN ENESEKRELV FKEDGQEYAQ VIKMLGNGRL EALCFDGVKR LCHIRGKLRK KVWINTSDII LVGLRDYQDN KADVILKYNA DEARSLKAYG ELPEHAKINE TDTFGPGDDD EIQFDDIGDD DEDIDDI |
EIF1AY is comparable to eukaryotic translation initiation factor 1A (EIF1A). EIF1AY protein is essential for highest rate of protein biosynthesis. EIF1AY increases ribosome dissociation into subunits and is obligatory for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
EIF1AY produced in E.Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids (1-144.a.a) and having a molecular mass of 18.8kDa. EIF1AY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EIF1AY: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. Belongs to the eIF-1A family. |
| UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: Yq11.223 Molecular Function:protein binding; translation initiation factor activity Biological Process: translational initiation |
| NCBI Summary: | This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O14602 |
| NCBI GenInfo Identifier: | 25014072 |
| NCBI Gene ID: | 9086 |
| NCBI Accession: | O14602.4 |
| UniProt Secondary Accession: | O14602,Q9BS77, |
| UniProt Related Accession: | O14602 |
| Molecular Weight: | 16,442 Da |
| NCBI Full Name: | Eukaryotic translation initiation factor 1A, Y-chromosomal |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 1A, Y-linked |
| NCBI Official Symbol: | EIF1AY |
| NCBI Official Synonym Symbols: | eIF-4C |
| NCBI Protein Information: | eukaryotic translation initiation factor 1A, Y-chromosomal; eIF-1A Y isoform; eukaryotic translation initiation factor 1A, Y chromosome; eukaryotic translation initiation factor 4C |
| UniProt Protein Name: | Eukaryotic translation initiation factor 1A, Y-chromosomal |
| UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 4C; eIF-4C |
| Protein Family: | Eukaryotic translation initiation factor |
| UniProt Gene Name: | EIF1AY |
| UniProt Entry Name: | IF1AY_HUMAN |
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