Human EIF1AX Recombinant Protein (RPPB3420)

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SKU:
RPPB3420
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
EIF1AX
Synonyms:
eukaryotic translation initiation factor 1A
Synonyms:
X-linked
Synonyms:
eIF-4C
Synonyms:
EIF1A
Source:
Escherichia Coli
Uniprot:
P47813
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Description

Product Name:Human EIF1AX Recombinant Protein
Product Code:RPPB3420
Size:20µg
Species:Human
Target:EIF1AX
Synonyms:eukaryotic translation initiation factor 1A, X-linked, eIF-4C, EIF1A, EIF4C, eIF-1A, EIF1AP1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The EIF1AX protein solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH8.0) containing 5mM DTT, 200mM NaCl and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI

EIF1AX is an important eukaryotic translation initiation factor. EIF1AX is essential for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5'' end of capped RNA. EIF1AP1 is needed for maximal rate of protein biosynthesis. EIF1AX increases ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA (I) to 40 S ribosomal subunits.

EIF1AX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-144a.a.) and having a molecular wieght of 18.6kDa. EIF1AX is fused to 20a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:EIF1AX: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. Belongs to the eIF-1A family
UniProt Protein Details:

Protein type:Translation initiation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: Xp22.12

Cellular Component: cytosol

Molecular Function:protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression

NCBI Summary:This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
UniProt Code:P47813
NCBI GenInfo Identifier:1352425
NCBI Gene ID:1964
NCBI Accession:P47813.2
UniProt Secondary Accession:P47813,Q0VGC2, Q5JPS5, Q5JPS6, B2R5U5,
UniProt Related Accession:P47813
Molecular Weight:Calculated: 16kDaObserved: 16kDa
NCBI Full Name:Eukaryotic translation initiation factor 1A, X-chromosomal
NCBI Synonym Full Names:eukaryotic translation initiation factor 1A, X-linked
NCBI Official Symbol:EIF1AX  
NCBI Official Synonym Symbols:EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1  
NCBI Protein Information:eukaryotic translation initiation factor 1A, X-chromosomal; eIF-1A X isoform; eukaryotic translation initiation factor 4C; Putative eukaryotic translation initiation factor 1A; eukaryotic translation initiation factor 1A, X chromosome
UniProt Protein Name:Eukaryotic translation initiation factor 1A, X-chromosomal
UniProt Synonym Protein Names:Eukaryotic translation initiation factor 4C; eIF-4C
Protein Family:Eukaryotic translation initiation factor
UniProt Gene Name:EIF1AX  
UniProt Entry Name:IF1AX_HUMAN
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