Human DYRK1A Recombinant Protein (RPPB2500)

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주문
SKU:
RPPB2500
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
DYRK1A
Synonyms:
Dual Specificity Yak1-related kinase
Synonyms:
Dyrk
Synonyms:
PSK47
Synonyms:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Source:
Escherichia Coli
Uniprot:
Q63470
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Description

Product Name:Human DYRK1A Recombinant Protein
Product Code:RPPB2500
Size:20µg
Species:Human
Target:DYRK1A
Synonyms:Dual Specificity Yak1-related kinase, Dyrk; PSK47, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, Protein kinase minibrain homolog, RP86, Dyrk1a, MNBH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DYRK1A solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH RSYEIDSLIG KGSFGQVVKA YDRVEQEWVA IKIIKNKKAF LNQAQIEVRL LELMNKHDTE MKYYIVHLKR HFMFRNHLCL VFEMLSYNLY DLLRNTNFRG VSLNLTRKFA QQMCTALLFL ATPELSIIHC DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS LGCILVEMHT GEPLFSGANE VDQMNKIVEV LGIPPAHILD QAPKARKFFE KLPDGTWSLK KTKDGKREYK PPGTRKLHNI LGVETGGPGG RRAGESGHTV ADYLKFKDLI LRMLDYDPKT RIQPYYALQH SFF
UniProt Code:Q63470

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated 1A (DYRK1A) belongs to the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. DYRK1A includes a nuclear targeting signal sequence, a leucine zipper motif and a protein kinase domain. DYRK1A catalyzes its autophosphorylation on serine/threonine and tyrosine residues and takes part in a signaling pathway regulating cell proliferation. DYRK1A has a substrate preference for proline at position P+1 and arginine at position P-3.

DYRK1A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (159-479a.a) and having a molecular mass of 39.4kDa. DYRK1A is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

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