Human DsbA Recombinant Protein (RPPB1586)

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SKU:
RPPB1586
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
DsbA
Synonyms:
Disulfide oxidoreductase A
Synonyms:
dsbA
Synonyms:
rpbB
Synonyms:
Disulfide oxidoreductase (DsbA) E Coli
Source:
Escherichia Coli
Uniprot:
P0AEG4
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Description

Product Name:Human DsbA Recombinant Protein
Product Code:RPPB1586
Size:50µg
Species:Human
Target:DsbA
Synonyms:Disulfide oxidoreductase A, dsbA, rpbB, Disulfide oxidoreductase (DsbA) E Coli, DsDNA-binding protein A, Doublestranded DNA-binding protein, Disulfide oxidoreductase A periplasmic protein disulfide isomerase I, Thiol disulfide interchange protein dsbA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:DsbA Human protein (1mg/ml) is formulated in 20mM Tris-HCl buffer (pH 7.5) and 2mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MAQYEDGKQY TTLEKPVAGA PQVLEFFSFF CPHCYQFEEV LHISDNVKKK LPEGVKMTKY HVNFMGGDLG KDLTQAWAVA MALGVEDKVT VPLFEGVQKT QTIRSASDIR DVFINAGIKG EEYDAAWNSF VVKSLVAQQE KAAADVQLRG VPAMFVNGKY QLNPQGMDTS NMDVFVQQYA DTVKYLSEKK

Disulfide Oxidoreductase or DsbA is a protein, found in the plasma. It is part of the thioredoxin protein family. The protein creates disulfide bonds in the target proteins by contributing disulfide bond from its Cys30-Pro31-His32-Cys33 active site to a couple of cysteine residues.

DsbA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids (20-208) and having a molecular mass of 21.2 kDa. DsbA Humanis purified by proprietary chromatographic techniques.

UniProt Protein Function:Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.
UniProt Protein Details:
NCBI Summary:DsbA has a role in cytochrome C synthesis. [More information is available at EcoGene: EG11297].
UniProt Code:P0AEG4
NCBI GenInfo Identifier:16131701
NCBI Gene ID:948353
NCBI Accession:NP_418297.1
UniProt Secondary Accession:P0AEG4,P24991, Q2M8F8, Q46951, Q46952
UniProt Related Accession:P0AEG4
Molecular Weight:23,105 Da
NCBI Full Name:periplasmic protein disulfide isomerase I
NCBI Synonym Full Names:
NCBI Official Symbol:dsbA  
NCBI Official Synonym Symbols:dsf; ECK3852; iarA; JW3832; ppfA  
NCBI Protein Information:periplasmic protein disulfide isomerase I
UniProt Protein Name:Thiol:disulfide interchange protein DsbA
UniProt Synonym Protein Names:
Protein Family:Double-stranded DNA-binding protein
UniProt Gene Name:dsbA  
UniProt Entry Name:DSBA_ECOLI
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