Human DNAJB4 Recombinant Protein (RPPB5202)

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SKU:
RPPB5202
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DNAJB4
Synonyms:
DnaJ homolog subfamily B member 4
Synonyms:
Heat shock 40 kDa protein 1 homolog
Synonyms:
HSP40 homolog
Synonyms:
Heat shock protein 40 homolog
Source:
Escherichia Coli
Uniprot:
Q9UDY4
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Description

Product Name:Human DNAJB4 Recombinant Protein
Product Code:RPPB5202
Size:10µg
Species:Human
Target:DNAJB4
Synonyms:DnaJ homolog subfamily B member 4, Heat shock 40 kDa protein 1 homolog, HSP40 homolog, Heat shock protein 40 homolog, Human liver DnaJ-like protein, DNAJB4, DNAJW, HLJ1, DjB4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:DNAJB4 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.2M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGKDYYC ILGIEKGASD EDIKKAYRKQ ALKFHPDKNK SPQAEEKFKE VAEAYEVLSD PKKREIYDQF GEEGLKGGAG GTDGQGGTFR YTFHGDPHAT FAAFFGGSNP FEIFFGRRMG GGRDSEEMEI DGDPFSAFGF SMNGYPRDRN SVGPSRLKQD PPVIHELRVS LEEIYSGCTK RMKISRKRLN ADGRSYRSED KILTIEIKKG WKEGTKITFP REGDETPNSI PADIVFIIKD KDHPKFKRDG SNIIYTAKIS LREALCGCSI NVPTLDGRNI PMSVNDIVKP GMRRRIIGYG LPFPKNPDQR GDLLIEFEVS FPDTISSSSK EVLRKHLPAS

DnaJ (Hsp40) Homolog, Subfamily B, Member 4 (DNAJB4) is a member of the evolutionarily conserved DNAJ/HSP40 protein family. DNAJB4 subunit configuration is homodimer. DNAJB4 possibly functions as a chaperone. DNAJB4 C-terminal section interacts with the C-terminal tail of OPRM1. DNAJB4 also has an interaction with SDIM1. DNAJB4 is expressed in the heart, pancreas and skeletal muscle, and to a lesser extent in the brain, placenta and liver.

DNAJB4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 360 amino acids (1-337 a.a.) and having a molecular mass of 40kDa.DNAJB4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DNAJB4: Probable chaperone. Homodimer. The C-terminal section interacts with the C- terminal tail of OPRM1. Interacts also with SDIM1. By heat shock. Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function:chaperone binding; protein binding; unfolded protein binding

Biological Process: protein folding; response to heat; response to unfolded protein

NCBI Summary:The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:Q9UDY4
NCBI GenInfo Identifier:8928155
NCBI Gene ID:11080
NCBI Accession:Q9UDY4.1
UniProt Secondary Accession:Q9UDY4,Q13431, B2R824,
UniProt Related Accession:Q9UDY4
Molecular Weight:37,807 Da
NCBI Full Name:DnaJ homolog subfamily B member 4
NCBI Synonym Full Names:DnaJ heat shock protein family (Hsp40) member B4
NCBI Official Symbol:DNAJB4  
NCBI Official Synonym Symbols:DjB4; HLJ1; DNAJW  
NCBI Protein Information:dnaJ homolog subfamily B member 4
UniProt Protein Name:DnaJ homolog subfamily B member 4
UniProt Synonym Protein Names:Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein
Protein Family:DnaJ homolog subfamily
UniProt Gene Name:DNAJB4  
UniProt Entry Name:DNJB4_HUMAN
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