Human DNAJB11 Recombinant Protein (RPPB5200)

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SKU:
RPPB5200
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
DNAJB11
Synonyms:
DnaJ homolog subfamily B member 11
Synonyms:
APOBEC1-binding protein 2
Synonyms:
ABBP-2
Synonyms:
DnaJ protein homolog 9
Source:
Escherichia Coli
Uniprot:
Q9UBS4
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Description

Product Name:Human DNAJB11 Recombinant Protein
Product Code:RPPB5200
Size:5µg
Species:Human
Target:DNAJB11
Synonyms:DnaJ homolog subfamily B member 11, APOBEC1-binding protein 2, ABBP-2, DnaJ protein homolog 9, ER-associated DNAJ, ER-associated Hsp40 co-chaperone, ER-associated dnaJ protein 3, ERdj3, ERj3p, HEDJ, Human DnaJ protein 9, hDj-9, PWP1-interacting protein 4, DNAJB11, EDJ, ERJ3, HDJ9, DJ9, Dj-9, ABBP2, UNQ537, PRO1080.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DNAJB11 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2mM DTT and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGRDFYKILG VPRSASIKDI KKAYRKLALQ LHPDRNPDDP QAQEKFQDLG AAYEVLSDSE KRKQYDTYGE EGLKDGHQSS HGDIFSHFFG DFGFMFGGTP RQQDRNIPRG SDIIVDLEVT LEEVYAGNFV EVVRNKPVAR QAPGKRKCNC RQEMRTTQLG PGRFQMTQEV VCDECPNVKL VNEERTLEVE IEPGVRDGME YPFIGEGEPH VDGEPGDLRF RIKVVKHPIF ERRGDDLYTN VTISLVESLV GFEMDITHLD GHKVHISRDK ITRPGAKLWK KGEGLPNFDN NNIKGSLIIT FDVDFPKEQL TEEAREGIKQ LLKQGSVQKV YNGLQGY

DNAJB11 is a member of the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJB11 serves as a co-chaperone for HSPA5 and binds directly to both unfolded proteins which are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed.

DNAJB11 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (23-358 a.a.) and having a molecular mass of 40.5kDa.DNAJB11 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DNAJB11: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Endoplasmic reticulum; RNA processing; Chaperone

Chromosomal Location of Human Ortholog: 3q27.3

Cellular Component: membrane; endoplasmic reticulum; endoplasmic reticulum lumen; nucleus

Molecular Function:protein binding; unfolded protein binding

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; mRNA modification

NCBI Summary:This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
UniProt Code:Q9UBS4
NCBI GenInfo Identifier:18203497
NCBI Gene ID:51726
NCBI Accession:Q9UBS4.1
UniProt Secondary Accession:Q9UBS4,Q542Y5, Q542Y9, Q6IAQ8, Q96JC6,
UniProt Related Accession:Q9UBS4
Molecular Weight:358
NCBI Full Name:DnaJ homolog subfamily B member 11
NCBI Synonym Full Names:DnaJ (Hsp40) homolog, subfamily B, member 11
NCBI Official Symbol:DNAJB11  
NCBI Official Synonym Symbols:DJ9; EDJ; Dj-9; ERj3; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080  
NCBI Protein Information:dnaJ homolog subfamily B member 11; DnaJ protein 9; APOBEC1-binding protein 2; ER-resident protein ERdj3; PWP1-interacting protein 4; ER-associated DNAJ protein 3; ER-associated Hsp40 co-chaperone; endoplasmic reticulum DNA J domain-containing protein 3
UniProt Protein Name:DnaJ homolog subfamily B member 11
UniProt Synonym Protein Names:APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4
Protein Family:DnaJ homolog subfamily
UniProt Gene Name:DNAJB11  
UniProt Entry Name:DJB11_HUMAN
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