Human DIRAS1 Recombinant Protein (RPPB3353)

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SKU:
RPPB3353
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DIRAS1
Synonyms:
GTP-binding protein Di-Ras1
Synonyms:
Distinct subgroup of the Ras family member 1
Synonyms:
Ras-related inhibitor of cell growth
Synonyms:
Rig
Source:
Escherichia Coli
Uniprot:
O95057
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Description

Product Name:Human DIRAS1 Recombinant Protein
Product Code:RPPB3353
Size:10µg
Species:Human
Target:DIRAS1
Synonyms:GTP-binding protein Di-Ras1, Distinct subgroup of the Ras family member 1, Ras-related inhibitor of cell growth, Rig, Small GTP-binding tumor suppressor 1, DIRAS1, GBTS1, Di-Ras1, FLJ42681.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:DIRAS1 Human solution (1mg/ml) containing 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 1mM DTT, 0.1M NaCl and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG KCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR KGKC

DIRAS1 is a member of a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases. DIRAS1 demonstrates low GTPase activity and exists mainly in the GTP-bound form. Ras proteins operate as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways regulate such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are frequently deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis.

DIRAS1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 215 amino acids (1-195a.a.) and having a molecular mass of 24.1 kDa. DIRAS1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

UniProt Protein Function:DIRAS1: Displays low GTPase activity and exist predominantly in the GTP-bound form. Belongs to the small GTPase superfamily. Di-Ras family.Protein type: G protein, monomeric, di-Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: GTP binding; GTPase activity; mitogen-activated protein kinase bindingBiological Process: positive regulation of MAP kinase activity
UniProt Protein Details:
NCBI Summary:DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
UniProt Code:O95057
NCBI GenInfo Identifier:62286591
NCBI Gene ID:148252
NCBI Accession:O95057.1
UniProt Secondary Accession:O95057
UniProt Related Accession:O95057
Molecular Weight:22,329 Da
NCBI Full Name:GTP-binding protein Di-Ras1
NCBI Synonym Full Names:DIRAS family GTPase 1
NCBI Official Symbol:DIRAS1  
NCBI Official Synonym Symbols:RIG; GBTS1; Di-Ras1  
NCBI Protein Information:GTP-binding protein Di-Ras1
UniProt Protein Name:GTP-binding protein Di-Ras1
UniProt Synonym Protein Names:Distinct subgroup of the Ras family member 1; Ras-related inhibitor of cell growth; Rig; Small GTP-binding tumor suppressor 1
Protein Family:GTP-binding protein
UniProt Gene Name:DIRAS1  
UniProt Entry Name:DIRA1_HUMAN
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