Human DCT Recombinant Protein (RPPB1557)

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SKU:
RPPB1557
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DCT
Synonyms:
L-dopachrome tautomerase (EC:53312)
Synonyms:
DCT
Synonyms:
DT
Synonyms:
L-dopachromeDelta-isomerase Tyrosinase-related protein2
Source:
Sf9 Insect cells
Uniprot:
P40126
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Description

Product Name:Human DCT Recombinant Protein
Product Code:RPPB1557
Size:10µg
Species:Human
Target:DCT
Synonyms:L-dopachrome tautomerase (EC:5.3.3.12), DCT, DT, L-dopachromeDelta-isomerase Tyrosinase-related protein2, TRP-2, TRP2, TYRP2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:STK3 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:QFPRVCMTVD SLVNKECCPRLGAESANVCG SQQGRGQCTE VRADTRPWSG PYILRNQDDR ELWPRKFFHR TCKCTGNFAG YNCGDCKFGW TGPNCERKKP PVIRQNIHSL SPQEREQFLG ALDLAKKRVH PDYVITTQHW LGLLGPNGTQ PQFANCSVYDFFVWLHYYSV RDTLLGPGRP YRAIDFSHQG PAFVTWHRYH LLCLERDLQR LIGNESFALP YWNFATGRNECDVCTDQLFG AARPDDPTLI SRNSRFSSWE TVCDSLDDYN HLVTLCNGTY EGLLRRNQMG RNSMKLPTLK DIRDCLSLQK FDNPPFFQNS TFSFRNALEG FDKADGTLDS QVMSLHNLVH SFLNGTNALP HSAANDPIFVVLHSFTDAIF DEWMKRFNPP ADAWPQELAP IGHNRMYNMV PFFPPVTNEE LFLTSDQLGY SYAIDLPVSVEETPGWPTTH HHHHH

Dopachrome Tautomerase also known as DCT,belongs to the tyrosinase family. DCT takes a significant part in the synthesisof the melanin pigment including tyrosinase (Tyr), tyrosinase-related protein 1(Tyrp1). Which are highly involved in eumelanin synthesis. The change among theeumelanin and the pheomelanin pathways is assumed to depend on the presence ofcysteine. Hence, in the lack of cysteine, dopaquinone, the product oftyrosinase action, is transformed to cyclodopa (leucodopachrome) and afterwardsto dopachrome (and DOPA).

DCT Human Recombinant produced in Sf9 Insect cell is asingle, non-glycosylated polypeptide chain containing 455 amino acids (24-472aa.a)and having a molecular mass of 52.1kDa (Migrates at 50-70kDa on SDS-PAGE underreducing conditions). DCT is fused to a 6 amino acidHis tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:DCT: Involved in regulating eumelanin and phaeomelanin levels. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 5.3.3.12; Cell development/differentiation; Membrane protein, integral; Isomerase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: cytosol; melanosome; melanosome membrane

Molecular Function:copper ion binding; dopachrome isomerase activity; oxidoreductase activity

Biological Process: epidermis development; melanin biosynthetic process; melanin biosynthetic process from tyrosine

UniProt Code:P40126
NCBI GenInfo Identifier:731026
NCBI Gene ID:1638
NCBI Accession:P40126.1
UniProt Secondary Accession:P40126,Q09GT4,
UniProt Related Accession:P40126
Molecular Weight:62,929 Da
NCBI Full Name:L-dopachrome tautomerase
NCBI Synonym Full Names:dopachrome tautomerase
NCBI Official Symbol:DCT  
NCBI Official Synonym Symbols:TRP-2; TYRP2  
NCBI Protein Information:L-dopachrome tautomerase
UniProt Protein Name:L-dopachrome tautomerase
UniProt Synonym Protein Names:L-dopachrome Delta-isomerase; Tyrosinase-related protein 2; TRP-2; TRP2
Protein Family:dCTP deaminase
UniProt Gene Name:DCT  
UniProt Entry Name:TYRP2_HUMAN
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