Human CYTH1 Recombinant Protein (RPPB3321)

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SKU:
RPPB3321
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CYTH1
Synonyms:
Cytohesin 1
Synonyms:
D17S811E
Synonyms:
PH
Synonyms:
SEC7 And Coiled-CoilDomain-Containing Protein 1
Source:
Escherichia Coli
Uniprot:
Q15438
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Description

Product Name:Human CYTH1 Recombinant Protein
Product Code:RPPB3321
Size:20µg
Species:Human
Target:CYTH1
Synonyms:Cytohesin 1, D17S811E, PH, SEC7 And Coiled-CoilDomain-Containing Protein 1, Pleckstrin Homology, Sec7 And Coiled-Coil Domains1, SEC7 Homolog B2-1, PSCD1, SEC7, Homolog Of Secretory Protein SEC7, Cytoadhesin1, CYTOHESIN-1, B2-1, Cytohesin-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CYTH1 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEEDDSY VPSDLTAEER QELENIRRRK QELLADIQRL KDEIAEVANEIENLGSTEER KNMQRNKQVA MGRKKFNMDP KKGIQFLIEN DLLKNTCEDI AQFLYKGEGL NKTAIGDYLGERDEFNIQVL HAFVELHEFT DLNLVQALRQ FLWSFRLPGE AQKIDRMMEA FAQRYCQCNN GVFQSTDTCYVLSFAIIMLN TSLHNPNVKD KPTVERFIAM NRGINDGGDL PEELLRNLYE SIKNEPFKIP EDDGNDLTHTFFNPDREGWL LKLGGGRVKT WKRRWFILTD NCLYYFEYTT DKEPRGIIPL ENLSIREVED SKKPNCFELYIPDNKDQVIK ACKTEADGRV VEGNHTVYRI SAPTPEEKEE WIKCIKAAIS RDPFYEMLAA RKKKVSSTKR H

Cytohesin 1 also known as CYTH1 belongs to the PSCD family. CYTH1is responsible for promoting guanine-nucleotide exchange on ARF1 and ARF5 and alsopromotes the activation of ARF factors by the replacement of GDP with GTP.

CYTH1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 421 amino acids (1-398 a.a) andhaving a molecular mass of 48.8kDa.CYTH1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:cytohesin 1: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; GEFs; GEFs, ARF

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: extrinsic to internal side of plasma membrane; tight junction; cytoplasm; plasma membrane; trans-Golgi network; cytosol

Molecular Function:protein binding; lipid binding; ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; regulation of cell adhesion; regulation of ARF protein signal transduction; positive regulation of GTPase activity

NCBI Summary:The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:Q15438
NCBI GenInfo Identifier:2498175
NCBI Gene ID:9267
NCBI Accession:Q15438.1
UniProt Secondary Accession:Q15438,Q9P123, Q9P124, A6NFW7, B7Z1T4,
UniProt Related Accession:Q15438
Molecular Weight:39,470 Da
NCBI Full Name:Cytohesin-1
NCBI Synonym Full Names:cytohesin 1
NCBI Official Symbol:CYTH1  
NCBI Official Synonym Symbols:B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1  
NCBI Protein Information:cytohesin-1; PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog B2-1; cytoadhesin 1; homolog of secretory protein SEC7; pleckstrin homology, Sec7 and coiled-coil domains 1
UniProt Protein Name:Cytohesin-1
UniProt Synonym Protein Names:PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog B2-1
Protein Family:Cytohesin
UniProt Gene Name:CYTH1  
UniProt Entry Name:CYH1_HUMAN
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