Human CRYZ Recombinant Protein (RPPB3274)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB3274
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CRYZ
Synonyms:
Quinone oxidoreductase
Synonyms:
NADPH:quinone reductase
Synonyms:
Zeta-crystallin
Synonyms:
CRYZ
Source:
Escherichia Coli
Uniprot:
Q08257
€0.00
Frequently bought together:

Description

Product Name:Human CRYZ Recombinant Protein
Product Code:RPPB3274
Size:20µg
Species:Human
Target:CRYZ
Synonyms:Quinone oxidoreductase, NADPH:quinone reductase, Zeta-crystallin, CRYZ, Quinone oxidoreductase isoform a, Crystallin, zeta (quinone reductase), Crystallin Zeta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CRYZ protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMATGQKL MRAVRVFEFG GPEVLKLRSD IAVPIPKDHQ VLIKVHACGV NPVETYIRSG TYSRKPLLPY TPGSDVAGVI EAVGDNASAF KKGDRVFTSS TISGGYAEYA LAADHTVYKL PEKLDFKQGA AIGIPYFTAY RALIHSACVK AGESVLVHGA SGGVGLAACQ IARAYGLKIL GTAGTEEGQK IVLQNGAHEV FNHREVNYID KIKKYVGEKG IDIIIEMLAN VNLSKDLSLL SHGGRVIVVG SRGTIEINPR DTMAKESSII GVTLFSSTKE EFQQYAAALQ AGMEIGWLKP VIGSQYPLEK VAEAHENIIH GSGATGKMIL LL

Crystallin Zeta, also known as CRYZ, Binds NADP and participates in a one-electron transfer process. CRYZ takes part in the detoxification of xenobiotics and Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. CRYZ improves the mRNA coding for BCL2.

CRYZ Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 352 amino acids (1-329 a.a.) and having a molecular mass of 37.6kDa.CRYZ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CRYZ: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.6.5.5; Oxidoreductase; RNA-binding

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: cytoplasm; cytosol

Molecular Function:mRNA 3'-UTR binding; NADPH:quinone reductase activity

Biological Process: protein homotetramerization; visual perception; xenobiotic catabolic process

NCBI Summary:Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
UniProt Code:Q08257
NCBI GenInfo Identifier:585013
NCBI Gene ID:1429
NCBI Accession:Q08257.1
UniProt Secondary Accession:Q08257,Q53FT0, Q59EU7, Q5HYE7, Q6NSK9, A6NN60, D3DQ76
UniProt Related Accession:Q08257
Molecular Weight:31,528 Da
NCBI Full Name:Quinone oxidoreductase
NCBI Synonym Full Names:crystallin zeta
NCBI Official Symbol:CRYZ  
NCBI Protein Information:quinone oxidoreductase
UniProt Protein Name:Quinone oxidoreductase
UniProt Synonym Protein Names:NADPH:quinone reductase; Zeta-crystallin
Protein Family:Zeta-crystallin
UniProt Gene Name:CRYZ  
UniProt Entry Name:QOR_HUMAN
View AllClose

Related Products