Human CRABP1 Recombinant Protein (RPPB3244)

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SKU:
RPPB3244
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CRABP1
Synonyms:
Cellular retinoic acid-binding protein 1
Synonyms:
Cellular retinoic acid-binding protein I
Synonyms:
CRABP-I
Synonyms:
CRABP1
Source:
Escherichia Coli
Uniprot:
P29762
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Description

Product Name:Human CRABP1 Recombinant Protein
Product Code:RPPB3244
Size:20µg
Species:Human
Target:CRABP1
Synonyms:Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5, CRABP, CRABPI.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CRABP1 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE

CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.

CRABP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 137 amino acids and having a molecular mass of 15.5kDa. The CRABP1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CRABP1: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: cytosol

Molecular Function:protein binding; retinoid binding

Biological Process: multicellular organismal development; signal transduction

NCBI Summary:This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
UniProt Code:P29762
NCBI GenInfo Identifier:266904
NCBI Gene ID:1381
NCBI Accession:P29762.2
UniProt Secondary Accession:P29762,Q6IAY7, Q8WTV5,
UniProt Related Accession:P29762
Molecular Weight:16kDa
NCBI Full Name:Cellular retinoic acid-binding protein 1
NCBI Synonym Full Names:cellular retinoic acid binding protein 1
NCBI Official Symbol:CRABP1  
NCBI Official Synonym Symbols:RBP5; CRABP; CRABPI; CRABP-I  
NCBI Protein Information:cellular retinoic acid-binding protein 1
UniProt Protein Name:Cellular retinoic acid-binding protein 1
UniProt Synonym Protein Names:Cellular retinoic acid-binding protein I; CRABP-I
Protein Family:Cellular retinoic acid-binding protein
UniProt Gene Name:CRABP1  
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