Human CISD1 Recombinant Protein (RPPB3188)

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SKU:
RPPB3188
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CISD1
Synonyms:
CDGSH Iron Sulfur Domain 1
Synonyms:
Chromosome 10 Open Reading Frame 70
Synonyms:
CDGSH Iron Sulfur Domain-Containing Protein 1
Synonyms:
Zinc Finger CDGSH-Type Domain 1
Source:
Escherichia Coli
Uniprot:
Q9NZ45
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Description

Product Name:Human CISD1 Recombinant Protein
Product Code:RPPB3188
Size:20µg
Species:Human
Target:CISD1
Synonyms:CDGSH Iron Sulfur Domain 1, Chromosome 10 Open Reading Frame 70, CDGSH Iron Sulfur Domain-Containing Protein 1, Zinc Finger CDGSH-Type Domain 1, C10orf70, ZCD1, MitoNEET , MDS029.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CISD1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSKRFYVKD HRNKAMINLH IQKDNPKIVH AFDMEDLGDK AVYCRCWRSK KFPFCDGAHT KHNEETGDNV GPLIIKKKET

CISD1 protein holds a CDGSH iron-sulfur domain and is known to bind a redox-active [2Fe-2S] cluster. CISD1 is restricted to the outer membrane of mitochondria and takes part in oxidation regulation.

CISD1 Human Recombinant produced in E. coli is a single polypeptide chain containing 100 amino acids (32-108) and having a molecular mass of 11.4 kDa.CISD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ZCD1: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions. Belongs to the CISD protein family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: mitochondrion

NCBI Summary:This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
UniProt Code:Q9NZ45
NCBI GenInfo Identifier:25453105
NCBI Gene ID:55847
NCBI Accession:Q9NZ45.1
UniProt Secondary Accession:Q9NZ45,Q1X902,
UniProt Related Accession:Q9NZ45
Molecular Weight:12kDa
NCBI Full Name:CDGSH iron-sulfur domain-containing protein 1
NCBI Synonym Full Names:CDGSH iron sulfur domain 1
NCBI Official Symbol:CISD1  
NCBI Official Synonym Symbols:ZCD1; MDS029; C10orf70; mitoNEET  
NCBI Protein Information:CDGSH iron-sulfur domain-containing protein 1
UniProt Protein Name:CDGSH iron-sulfur domain-containing protein 1
UniProt Synonym Protein Names:MitoNEET
Protein Family:CDGSH iron-sulfur domain-containing protein
UniProt Gene Name:CISD1  
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