Human CIRBP Recombinant Protein (RPPB3187)

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SKU:
RPPB3187
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CIRBP
Synonyms:
Cold-inducible RNA-binding protein
Synonyms:
A18 hnRNP
Synonyms:
Glycine-rich RNA-binding protein CIRP
Synonyms:
CIRBP
Source:
Escherichia Coli
Uniprot:
Q14011
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Description

Product Name:Human CIRBP Recombinant Protein
Product Code:RPPB3187
Size:20µg
Species:Human
Target:CIRBP
Synonyms:Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CIRBP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE

Cold inducible RNA-binding protein (CIRBP) has a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRBP is believed to play a crucial role in the suppression of cellular proliferation in response to UV irradiation or extreme cold.

CIRBP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 20.8kDa.CIRBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
UniProt Code:Q14011
NCBI GenInfo Identifier:5921786
NCBI Gene ID:1153
NCBI Accession:Q14011.1
UniProt Secondary Accession:Q14011,B3KT17, B4E2X2,
UniProt Related Accession:Q14011
Molecular Weight:19kDa
NCBI Full Name:Cold-inducible RNA-binding protein
NCBI Synonym Full Names:cold inducible RNA binding protein
NCBI Official Symbol:CIRBP  
NCBI Official Synonym Symbols:CIRP  
NCBI Protein Information:cold-inducible RNA-binding protein
UniProt Protein Name:Cold-inducible RNA-binding protein
UniProt Synonym Protein Names:A18 hnRNP; Glycine-rich RNA-binding protein CIRP
Protein Family:Cold-inducible RNA-binding protein
UniProt Gene Name:CIRBP  
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