Human CHRNA6 Recombinant Protein (RPPB3183)

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SKU:
RPPB3183
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CHRNA6
Synonyms:
CHNRA6
Synonyms:
Neuronal acetylcholine receptor subunit alpha-6
Synonyms:
CHRNA6
Source:
Escherichia Coli
Uniprot:
Q15825
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Description

Product Name:Human CHRNA6 Recombinant Protein
Product Code:RPPB3183
Size:20µg
Species:Human
Target:CHRNA6
Synonyms:CHNRA6, Neuronal acetylcholine receptor subunit alpha-6, CHRNA6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CHRNA6 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKGCV GCATEERLFH KLFSHYNQFI RPVENVSDPV TVHFEVAITQ LANVDEVNQI METNLWLRHI WNDYKLRWDP MEYDGIETLR VPADKIWKPD IVLYNNAVGD FQVEGKTKAL LKYNGMITWT PPAIFKSSCP MDITFFPFDH QNCSLKFGSW TYDKAEIDLL IIGSKVDMND FWENSEWEII DASGYKHDIK YNCCEEIYTD ITYSFYIRRL

Cholinergic Receptor Nicotinic, Alpha 6 (CHRNA6) is a part of the nicotinic acetylcholine receptors (nAChRs) family. nAChRs are heteropentameric ligand-gated ion channels generating from the assembly of alpha and beta protein subunits. After binding acetylcholine, the AChRs respond by a major change in conformation which affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA6 receptors have a rather selective localization to the nigrostriatal pathway.

CHRNA6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (26-239 a.a) and having a molecular mass of 29.3kDa. CHRNA6 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
NCBI Summary:This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
UniProt Code:Q15825
NCBI GenInfo Identifier:313482792
NCBI Gene ID:8973
NCBI Accession:NP_001186208.1
UniProt Secondary Accession:Q15825,B2R8V4, B4DQH1,
UniProt Related Accession:Q15825
Molecular Weight:54
NCBI Full Name:neuronal acetylcholine receptor subunit alpha-6 isoform 2
NCBI Synonym Full Names:cholinergic receptor nicotinic alpha 6 subunit
NCBI Official Symbol:CHRNA6  
NCBI Official Synonym Symbols:CHNRA6  
NCBI Protein Information:neuronal acetylcholine receptor subunit alpha-6
UniProt Protein Name:Neuronal acetylcholine receptor subunit alpha-6
UniProt Gene Name:CHRNA6  
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