Human CHMP5 Recombinant Protein (RPPB3177)

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SKU:
RPPB3177
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CHMP5
Synonyms:
Charged Multivesicular Body Protein 5
Synonyms:
SNF7 Domain-Containing Protein 2
Synonyms:
Chromosome 9 Open Reading Frame 83
Synonyms:
Chromatin-Modifying Protein 5
Source:
Escherichia Coli
Uniprot:
Q9NZZ3
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Description

Product Name:Human CHMP5 Recombinant Protein
Product Code:RPPB3177
Size:20µg
Species:Human
Target:CHMP5
Synonyms:Charged Multivesicular Body Protein 5, SNF7 Domain-Containing Protein 2, Chromosome 9 Open Reading Frame 83, Chromatin-Modifying Protein 5, Apoptosis-Related Protein PNAS-2, Vacuolar Protein Sorting-Associated Protein 60, Chromatin Modifying Protein 5, HSPC177, PNAS-2, HVps60, SNF7DC2, CGI-34, C9orf83.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CHMP5 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSH MNRLFG KAKPKAPPPS LTDCIGTVDS RAESIDKKIS RLDAELVKYK DQIKKMREGP AKNMVKQKAL RVLKQKRMYE QQRDNLAQQS FNMEQANYTI QSLKDTKTTV DAMKLGVKEM KKAYKQVKID QIEDLQDQLE DMMEDANEIQ EALSRSYGTP ELDEDDLEAE LDALGDELLA DEDSSYLDEA ASAPAIPEGV PTDTKNKDGV LVDEFGLPQI PAS

Charged Multivesicular Body Protein 5 (CHMP5) is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins comprise the ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and development of endocytic multivesicular bodies (MVBs). Certain CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP the CHMP1A, is essential for both MVB formation and regulation of cell cycle progression.

CHMP5 Human Recombinant produced in E. coli is a single polypeptide chain containing 243 amino acids (1-219) and having a molecular mass of 27.0 kDa.CHMP5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CHMP5: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. Belongs to the SNF7 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: VesicleChromosomal Location of Human Ortholog: 9p13.3Cellular Component: cytosolMolecular Function: protein bindingBiological Process: cell separation during cytokinesis; endosome transport; mitotic metaphase plate congression; non-lytic virus budding; nuclear organization and biogenesis; viral infectious cycle
UniProt Protein Details:
NCBI Summary:CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NZZ3
NCBI GenInfo Identifier:51702157
NCBI Gene ID:51510
NCBI Accession:Q9NZZ3.1
UniProt Secondary Accession:Q9NZZ3,Q5VXW2, Q96AV2, Q9HB68, Q9NYS4, Q9Y323, B2RD95 B4DIR6
UniProt Related Accession:Q9NZZ3
Molecular Weight:19,520 Da
NCBI Full Name:Charged multivesicular body protein 5
NCBI Synonym Full Names:charged multivesicular body protein 5
NCBI Official Symbol:CHMP5  
NCBI Official Synonym Symbols:Vps60; CGI-34; PNAS-2; C9orf83; HSPC177; SNF7DC2  
NCBI Protein Information:charged multivesicular body protein 5
UniProt Protein Name:Charged multivesicular body protein 5
UniProt Synonym Protein Names:Chromatin-modifying protein 5; SNF7 domain-containing protein 2; Vacuolar protein sorting-associated protein 60; Vps60; hVps60
Protein Family:Charged multivesicular body protein
UniProt Gene Name:CHMP5  
UniProt Entry Name:CHMP5_HUMAN
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