Human CHMP1A Recombinant Protein (RPPB3172)

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SKU:
RPPB3172
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CHMP1A
Synonyms:
Charged multivesicular body protein 1a
Synonyms:
Chromatin-modifying protein 1a
Synonyms:
Vacuolar protein sorting-associated protein 46-1
Synonyms:
Vps46-1
Source:
Escherichia Coli
Uniprot:
Q9HD42
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Description

Product Name:Human CHMP1A Recombinant Protein
Product Code:RPPB3172
Size:10µg
Species:Human
Target:CHMP1A
Synonyms:Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, Vacuolar protein sorting-associated protein 46-1, Vps46-1, hVps46-1, CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1, PCH8, VPS46A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CHMP1A protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDDTLFQ LKFTAKQLEK LAKKAEKDSK AEQAKVKKAL LQKNVECARV YAENAIRKKN EGVNWLRMAS RVDAVASKVQ TAVTMKGVTK NMAQVTKALD KALSTMDLQK VSSVMDRFEQ QVQNLDVHTS VMEDSMSSAT TLTTPQEQVD SLIMQIAEEN GLEVLDQLSQ LPEGASAVGE SSVRSQEDQL SRRLAALRN

Charged multivesicular body protein 1a (CHMP1A) is a member of the vacuolar sorting protein family and functions as chromatin-modifying protein. These complexes are essential for sorting endosomal articles into multivesicular bodies (MVBs), as well as vital for the formation of these bodies. The MVBs pathway mediates distribution of transmembrane proteins into the lumen of the lysosome for degradation. CHMP1 interacts with VPS4B and localizes to early endosomes.

CHMP1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 219 amino acids (1-196 a.a.) and having a molecular mass of 24.1kDa (Molecular size on SDS-PAGE will appear higher).CHMP1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CHMP1A: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Belongs to the SNF7 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; Protease

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: condensed nuclear chromosome; early endosome; endomembrane system; microtubule organizing center; nuclear matrix

Molecular Function:identical protein binding; metallopeptidase activity; protein binding; protein domain specific binding; protein homodimerization activity; zinc ion binding

Biological Process: cell division; cell separation during cytokinesis; gene silencing; mitotic chromosome condensation; mitotic metaphase plate congression; negative regulation of transcription by glucose; negative regulation of transcription, DNA-dependent; nuclear organization and biogenesis; vesicle-mediated transport

Disease: Pontocerebellar Hypoplasia, Type 8

NCBI Summary:This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:Q9HD42
NCBI GenInfo Identifier:62510514
NCBI Gene ID:5119
NCBI Accession:Q9HD42.1
UniProt Secondary Accession:Q9HD42,Q14468, Q15779, Q96G31, A2RU09,
UniProt Related Accession:Q9HD42
Molecular Weight:22kDa
NCBI Full Name:Charged multivesicular body protein 1a
NCBI Synonym Full Names:charged multivesicular body protein 1A
NCBI Official Symbol:CHMP1A  
NCBI Official Synonym Symbols:PCH8; CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1  
NCBI Protein Information:charged multivesicular body protein 1a
UniProt Protein Name:Charged multivesicular body protein 1a
UniProt Synonym Protein Names:Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1; Vps46-1; hVps46-1
Protein Family:Charged multivesicular body protein
UniProt Gene Name:CHMP1A  
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