Human CHI3L1 Recombinant Protein (RPPB1490)
- SKU:
- RPPB1490
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- CHI3L1
- Synonyms:
- Chitinase 3-like 1
- CHI3L1
- Chitinase-3-like protein 1
- 39 kDa synovial protein
- Source:
- Chinese Hamster Ovary Cells (CHO)
- Uniprot:
- P36222
Description
| Product Name: | Human CHI3L1 Recombinant Protein |
| Product Code: | RPPB1490 |
| Size: | 5µg |
| Species: | Human |
| Target: | CHI3L1 |
| Synonyms: | Chitinase 3-like 1, CHI3L1, Chitinase-3-like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39, CGP-39, GP-39, hCGP-39. |
| Source: | Chinese Hamster Ovary Cells (CHO) |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CHI3L1 solution (0.25mg/ml) contains Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AATKLGPEQK LISEEDLNSA VDHHHHHH |
Chitinase 3-Like 1 (CHI3L1) catalyze the hydrolysis of chitin that is an abundant glycopolymer present in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases comprises 8 human family members. CHI3L1 belongs to the glycosyl hydrolase 18 family. CHI3L1 lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 takes part in the process of inflammation and tissue remodeling.
CHI3L1 Human Recombinant produced in CHO is a single, glycosylated polypeptide chain containing 408 amino acids (1-383) and having a molecular mass of 45.5kDa. CHI3L1 is fused to a 25 amino acid myc-His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cell adhesion Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm Molecular Function:extracellular matrix structural constituent; chitin binding; chitinase activity; carbohydrate binding Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; response to mechanical stimulus; cartilage development; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development Disease: Schizophrenia; Asthma-related Traits, Susceptibility To, 7 |
| NCBI Summary: | Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P36222 |
| NCBI GenInfo Identifier: | 84028186 |
| NCBI Gene ID: | 1116 |
| NCBI Accession: | P36222.2 |
| UniProt Secondary Accession: | P36222,P30923, Q8IVA4, Q96HI7, B2R7B0, |
| UniProt Related Accession: | P36222 |
| Molecular Weight: | 42,625 Da |
| NCBI Full Name: | Chitinase-3-like protein 1 |
| NCBI Synonym Full Names: | chitinase 3-like 1 (cartilage glycoprotein-39) |
| NCBI Official Symbol: | CHI3L1 |
| NCBI Official Synonym Symbols: | GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39 |
| NCBI Protein Information: | chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39 |
| UniProt Protein Name: | Chitinase-3-like protein 1 |
| UniProt Synonym Protein Names: | 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40 |
| Protein Family: | Chitinase-3-like protein |
| UniProt Gene Name: | CHI3L1 |
| UniProt Entry Name: | CH3L1_HUMAN |
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